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Silymarin

Overview

Silymarin is the active principle from the fruit of Silybum marianum. Silymarin is a free radical scavenger, used for the treatment of hepatic disorders.

Category:

Primary Characterstics

Molecular Structure of Silymarin
belongs to Chromanones. It belongs to Cholagogues pharmacological group.

Pharmacokinetics

Renal Excretion accounts for 80 % .

Indications

Silymarin is primarily indicated in conditions like Hepatitis, Hepatitis A infection, Jaundice, and can also be given in adjunctive therapy as an alternative drug of choice in Cirrhosis.

Contraindications

Drug Interactions

No data regarding the interactions of Silymarin was found.

Interference in Pathology

No data regarding the pathological interferences produced by Silymarin is available.

Side Effects

The signs and symptoms that are produced after the acute overdosage of Silymarin include Diarrhea.

The symptomatic adverse reactions produced by Silymarin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Headache, Joint pain, Stomach upset.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Syrup: 100 mg/5ml, 105 mg/5ml,
Susp: 105 mg/5ml,
Tabs: 20 mg, 200 mg,
Caps: 200 mg,

Multi ingredient

Susp: 105 mg/5ml,
Caps: 105 mg,

Dosage

Silymarin's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

200 mg200 (200)12 hourlyPO

Paedriatic Dosage ( 20 Kg. )

20 to 40 mg/kg30 (30)12 hourlyOral

Neonatal Dosage ( 3 Kg. )

No data regarding the neonatal dosage details of Silymarin is available.

High Risk Groups

Drug should not be given to Paediatrics, and Pregnant Mothers.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Should not be used by pregnant or breastfeeding women. People with a history of hormone-related cancers, including breast and uterine cancer and prostate cancer, should not take Silymarin. Should be use with caution in children.

Storage Conditions

Tabs, caps, syrups

Store in a well closed container, at room temperature, . Protect from Moisture and Heat.

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