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Levosulpiride is a substituted benzamide antipsychotic which is reported to be a selective antagonist of central dopamine (D-2, D-3 and D-4) receptors. Levosulpiride is also calimed to have mood elevating properties. Levosulpiride is used in the treatment of psychoses such as schizophrenia, anxiety disorders, vertigo and also in peptic ulceration.


Primary Characterstics

Molecular Structure of Levosulpiride
belongs to Sulphamoylbenzamide. It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antidepressant pharmacological group.The Molecular Weight of Levosulpiride is 341.40.
It is weakly alkaline drug.


Oral absorption of Levosulpiride is found to be 35% ±5. Plasma protien binding is >40 %. and metabolism is reported hepatic. Renal Excretion accounts for Unchanged 25% and plasma half life is 8-9 hr.


Levosulpiride is primarily indicated in conditions like Anxiety, Depression, Gastro-esophageal reflux disease, Irritable bowel syndrome, Schizophrenia, Tourette's syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in Peptic ulcer, Vertigo.


Drug Interactions

No data regarding the interactions of Levosulpiride was found.

Interference in Pathology

No data regarding the pathological interferences produced by Levosulpiride is available.

Side Effects

The severe or irreversible adverse effects of Levosulpiride, which give rise to further complications include Amenorrhea, Gynacomastia, Galactorrhea, Changes in libido.

Levosulpiride produces potentially life-threatening effects which include Neuroleptic Malignant Syndrome, Neuroleptic malignant syndrome. which are responsible for the discontinuation of Levosulpiride therapy.

The symptomatic adverse reactions produced by Levosulpiride are more or less tolerable and if they become severe, they can be treated symptomatically, these include Sedation, Sleep disturbance, Hypotension, Gynecomastia, Galactorrhea, Agitation, Dyskinesia, Overstimulation, Hyperprolactinemia, Tardive dyskinesia.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Tabs: 25 mg, 50 mg, 100 mg,
Caps: 25 mg, 50 mg,


Levosulpiride's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

200 to 800 mg500 (500)24 hourlyIM
200 to 400 mg300 (300)12 hourlyPOFor the treatment of schizophrenia: upto 1200mg twice daily may be given in patients with positive symptoms or upto 800 mg in patients with mainly negative symptoms.
25 to 25 mg25 (25)8 hourlyPOFor GERD, irritable bowel disease (IBS), dyspeptic syndrome, essential cephalgia.

Paedriatic Dosage ( 20 Kg. )

3 to 5 mg/kg4 (4)As recommended.POThis is the dose for children above 14 years of age. (i.e. 3-5mg/Kg daily)

Neonatal Dosage ( 3 Kg. )

Not recommended in this age group

High Risk Groups

Drug should not be given to Paediatrics, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Should be use with caution in porphyria,renal impairment and mania and in patients receiving antihypertensive, hypnotic and analgesic drugs, because concurrent use may increase the effects of these drugs.should be given with care to hypomanic pateints.

Storage Conditions

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