Ceftriaxone is a third generation, semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Ceftriaxone is a broad spectrum, ß lactmase resistant antibiotic effective against a wide range of gram positive and gram negative bacterias. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Ceftriaxone (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Ceftriaxone (Na) also known as Ceftriaxone. . It is of Semi Synthetic origin and belongs to Cephalosporin. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-3rd Gen pharmacological group.The Molecular Weight of Ceftriaxone (Na) is 600.60. It is weakly acidic drug.
Volume of distribution is found to be 0.15 l/kg and plasma protien binding is 95%. and metabolism is reported hepatic. Renal Excretion accounts for 56%, 44% in feces and also excreted in bile and plasma half life is 6-9 hr.
Ceftriaxone (Na) is primarily indicated in conditions like
Bacteremia, Benign gastric, duodenal or NSAID-associated ulceration, Bone and joint infection, Chancroid, Enteric fever, Gonococcal infections, Lower respiratory tract infections, Meningitis, Pneumonia, Pophylaxis of cardiac transplant rejection, Pophylaxis of hepatic transplant rejection, Septicaemia, Skin infections, Soft tissue infections, Surgical prophylaxis, Sympathetic block, Syphilis, Urinary tract infection.
No data regarding the interactions of Ceftriaxone (Na) was found.
Interference in Pathology
False low reading of urinary glucose testing by Clinitest
The severe or irreversible adverse effects of Ceftriaxone (Na), which give rise to further complications include Jaundice, Eosinophilia, Leucopenia, Neutropenia, Thrombocytosis, Erythema multiforme, Biliary pseudolithiasis, Hyperbilirubinemia.
Ceftriaxone (Na) produces potentially life-threatening effects which include Agranulocytosis, Pseudomembranous colitis. which are responsible for the discontinuation of Ceftriaxone (Na) therapy.
The signs and symptoms that are produced after the acute overdosage of Ceftriaxone (Na) include Burning sensation.
The symptomatic adverse reactions produced by Ceftriaxone (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Loose stools, Nausea, Vomiting, Diarrhea, Maculopapular rash, Urticaria, Pruritus, Local pain, Glossitis, StomatitisX, Edema, Local phlebitis.
Click on the appropriate strength of the dosage form to view its available brands.
Single Ingredient Inj: 1 g, 2 g, 1 gm, 250 mg, 500 mg, Inj-IV: 1 g, 250 mg, 500 mg, Inj-IM: 1 g, 250 mg, 500 mg, Inj CS: 250 mg, Inf: 1 g, Gel: 500 mg, Multi ingredient
Inj: 1 gm, 500 mg,
Ceftriaxone (Na)'s dosage details are as follows:
1 g 1 (1) 24 hourly 0.5-2 pre-operatively for prophylaxis against infection in surgery. 0.25 to 0.5 g 0.38 (0.375) As recommended. IM
1 to 2 g 1.5 (1.5) 24 hourly IV,IM Once daily or in two divided doses. Max. dose: 4 g/day. Given by IV infusion over atleast 30 minutes.
Paedriatic Dosage ( 20 Kg. )
50 mg/kg 50 (50) 24 hourly Intra Venous -
Neonatal Dosage ( 3 Kg. )
50 mg/kg 50 (50) 24 hourly Intra Venous -
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Warning / Precautions
Ceftriaxone should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs.
Dry Powder for Inj
Store at room temperature. Protect from Sunlight.
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