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Ceftriaxone (Na)


Ceftriaxone is a third generation, semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Ceftriaxone is a broad spectrum, ß lactmase resistant antibiotic effective against a wide range of gram positive and gram negative bacterias. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Ceftriaxone (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.


Primary Characterstics

Molecular Structure of Ceftriaxone (Na)
Ceftriaxone (Na) also known as Ceftriaxone. . It is of Semi Synthetic origin and belongs to Cephalosporin. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-3rd Gen pharmacological group.The Molecular Weight of Ceftriaxone (Na) is 661.60.
It is weakly acidic drug.


Volume of distribution is found to be 0.15 l/kg and plasma protien binding is 95%. and metabolism is reported hepatic. Renal Excretion accounts for 40% to 65% excreted unchanged in urine and plasma half life is 6-9 hr.



Ceftriaxone (Na) is contraindicated in conditions like Hypersensitivity.

Drug Interactions

No data regarding the interactions of Ceftriaxone (Na) was found.

Interference in Pathology

  • False low reading of urinary glucose testing by Clinitest

Side Effects

The severe or irreversible adverse effects of Ceftriaxone (Na), which give rise to further complications include Jaundice, Jaundice, Eosinophilia, Eosinophilia, Leucopenia, Neutropenia, Thrombocytosis, Erythema multiforme, Biliary pseudolithiasis, Hyperbilirubinemia, Erythema multiforme.

Ceftriaxone (Na) produces potentially life-threatening effects which include Agranulocytosis, Pseudomembranous colitis. which are responsible for the discontinuation of Ceftriaxone (Na) therapy.

The signs and symptoms that are produced after the acute overdosage of Ceftriaxone (Na) include Burning sensation.

The symptomatic adverse reactions produced by Ceftriaxone (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Loose stools, Nausea, Vomiting, Diarrhea, Maculopapular rash, Urticaria, Pruritus, Local pain, Glossitis, StomatitisX, Edema, Local phlebitis.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Inj: 1 g, 2 g, 250 mg, 500 mg,
Inj-IV: 1 g, 250 mg, 500 mg,
Inj-IM: 1 g, 2 g, 250 mg, 500 mg,
Inj IM/IV: 1 g, 250 mg, 500 mg,
Inj CS: 250 mg,
Inf: 1 g,
Gel: 500 mg,

Multi ingredient

Inj: 1 gm, 500 mg,


Ceftriaxone (Na)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

1 g1 (1)24 hourly0.5-2 pre-operatively for prophylaxis against infection in surgery.
0.25 to 0 g0.12 (0.125)As recommended.IMFor uncompleted Gonnorrhoea
1 to 2 g1.5 (1.5)24 hourlyIV,IMOnce daily or in two divided doses. Max. dose: 4 g/day. Given by IV infusion over atleast 30 minutes.

Paedriatic Dosage ( 20 Kg. )

0 to 125 mg62 (62.5)As recommended.For prevention of secondary cases of mennigococcal meningitis
20 to 50 mg/kg35 (35)24 hourlyIntra VenousFor serve infections up to 80mg/kg daily should be given

Neonatal Dosage ( 3 Kg. )

50 mg/kg50 (50)24 hourlyIntra VenousIV doses should be given over 60 min doses above 50mg/kg should be given by IV infusion only

High Risk Groups

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Ceftriaxone should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs.

Storage Conditions

Dry Powder for Inj

Store at room temperature. Protect from Sunlight.

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