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Manufacturer(s) of Cinnarizine in Pakistan.

EverestGlobalJanssen-Cilag
MederaMedisureMedley
SaffronSharex

Cinnarizine

Overview

Cinnarizine is antihistaminic agent. Cinnarizine is mainly used for treatment of vomiting and vertigo.

Category:

Primary Characterstics

Molecular Structure of Cinnarizine
. It is of Synthetic origin and belongs to Phenyl piperazine. It belongs to Calcium L-channel antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Cinnarizine is 368.50.

Pharmacokinetics

Metabolism is reported extensive. Renal Excretion accounts for 16.6 ± 7.5% and plasma half life is 3.04 ± 0.83 hr.

Indications

Cinnarizine is primarily indicated in conditions like Motion sickness, Peripheral arterial disease, Peripheral vascular disease, Raynaud`s syndrome, Vestibular disorders, Vestibular symptoms of central and peripheral origin, and can also be given in adjunctive therapy as an alternative drug of choice in Raynaud's disease.

Contraindications

Cinnarizine is contraindicated in conditions like Hypotension,Parkinson's disease.

Drug Interactions

No data regarding the interactions of Cinnarizine was found.

Interference in Pathology

No data regarding the pathological interferences produced by Cinnarizine is available.

Side Effects

The severe or irreversible adverse effects of Cinnarizine, which give rise to further complications include Tardive dyskinesia, Parkinsonism, Extrapyramidal symptoms.

The signs and symptoms that are produced after the acute overdosage of Cinnarizine include Convulsions, Drowsiness, Respiratory depression, Dizziness, Hypopyrexia, Incoordination.

The symptomatic adverse reactions produced by Cinnarizine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, GI upset, Unsteadiness.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Tabs: 25 mg,
Caps: 5 mg, 25 mg, 75 mg,

Multi ingredient

Tabs: 20 mg,

Dosage

Cinnarizine's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

25 to 75 mg50 (50)8 hourlyPOIn Motion sickness half an hour before travelling.

Paedriatic Dosage ( 20 Kg. )

0.6 mg/kg0.6 (0.6)8 hourlyOralNot recommended for below 5 yrs. Dose for 5-12 Yrs of Children

Neonatal Dosage ( 3 Kg. )

Not recommended under 5 yrs.of children

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Patients should observe caution while driving or performing other tasks requiring alertness, because may cause drowsiness. Cinnarizine should be used with caution in patients with liver impairment, dose should be reduced in patients with renal impairment. Avoid use in young children and use with caution in elderly patients.

Storage Conditions

Tab, Caps

Store at room temperature.

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