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Manufacturer(s) of Ergometrine (Maleate) in Pakistan.


Ergometrine (Maleate)


Ergometrine (Maleate) is a derivative of ergot (fungus). It produces contraction of uterine muscle and used after delivery of baby to prevent or reduce maternal haemorrhage.


  • 22 Obstetrics and gynecological preparations
  • 22.1 Labor inducers/inhibitors
  • 22.1.1 Oxytocics

Primary Characterstics

Ergometrine (Maleate) also known as Ergobasine Maleate, Ergobasine Maleate, Ergobasine Maleate, Ergobasine Maleate, Ergobasine Maleate, Ergobasine Maleate, Ergobasine Maleate. . It is of Natural origin and belongs to Ergot Alkaloid. It belongs to Alpha adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents and Anxiolytics pharmacological group.The Molecular Weight of Ergometrine (Maleate) is 441.50.
Its pKa is 6.73 ± 0.16.


Oral absorption of Ergometrine (Maleate) is found to be 97% ±2. Volume of distribution is found to be 73.4 ± 22 litre . Presystemic metabolism is noted to be 72.5% ±2.5 and metabolism is reported hepatic. Plasma half life is 0.5 hr.


Ergometrine (Maleate) is primarily indicated in conditions like Bleeding caused by uterine atony, Migraine, Postabrortal haemorrhage, Postpartum haemorrhage, Prevention and treatment of haemorrhage due to incomplete abortion, Routine management of the 3rd stage of labour, Uterine subinvolution, and can also be given in adjunctive therapy as an alternative drug of choice in Uterine atony.


Drug Interactions

Ergometrine (Maleate) is known to interact with other drugs, the details of drug interactions is as follows:

AdrenalineCoadministration increases blood pressure by vasoconstriction due to alpha adrenergic agonist activity of ergot alkaloids.ModerateCoadministration is not recommended. If use then close clinical monitoring of response, tolerance and excessive vasoconstriction is recommended.
EphedrineBoth agents acts additively and synergistically to produce vasoconstriction results in increased blood pressure.ModerateConcomitant use is considered contraindicated. Closely monitor for response and tolerance of patient.
ErythromycinCoadministration increases concentration of ergotamine in the plasma causing untoward peripheral vasoconstrictionModerateCoadministration is not recommended. If use then close clinical monitoring of response, tolerance and excessive vasoconstriction is recommended.
HalothaneHalothane decreases the oxytcic effects of ergonovine.MinorClosely monitor for change in efficacy during coadministration.
Ketamine (HCl)
MifepristoneOral contraceptive increase platelet aggregability and promote thrombus formationModeratesimultaneous use of ergometrine with oral contraceptives should be avoided
Oxprenolol (HCl)simultaneous use of ergometrine and b- adrenoceptor blocker may increase peripheral vascular resistance. increase risk of vascular occlusion . simultaneous use of ergometrine and b- adrenoceptor blocker should be avoided

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interference in Pathology

No data regarding the pathological interferences produced by Ergometrine (Maleate) is available.

Side Effects

The severe or irreversible adverse effects of Ergometrine (Maleate), which give rise to further complications include Vascular complications, Ischemia, Gangrene.

Ergometrine (Maleate) produces potentially life-threatening effects which include Coma, Seizures, Nausea, Vomiting, Hypertension, Hypotension, Diarrhea, Cold extremities, Severe thirst, Confusion. which are responsible for the discontinuation of Ergometrine (Maleate) therapy.

The signs and symptoms that are produced after the acute overdosage of Ergometrine (Maleate) include Nausea, Vomiting, Seizures, Angina, Confusion, Unconsciousness, Palpitations, Dizziness, Hypertension, Gangrene, Dyspnea, Vasoconstriction of the extremities.

The symptomatic adverse reactions produced by Ergometrine (Maleate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Palpitation, Tinnitus, Abdominal pain, VertigoX, Chest pain, Angina, Shortening of breath, Pulmonary edema, dizziness.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Tabs: 2 mg,


Ergometrine (Maleate)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

200 mcg200 (200)4 hourlyIMThis amount is given in emergencies such as uterine bleeding. Frequency may be increased from 2 to 4 hourly as needed, for maximum 5 doses. Or Single dose of 250 to 500 mcg can also be given.
200 mcg200 (200)As recommended.IMA usual dose of Ergometrine (Maleate) alone for prevention or treatment of postpartum or postabortal haemorrhage.
500 µg500 (500)As recommended.IMActive managment of 3rd stage of labour
200 to 400 mcg300 (300)6 hourlyPOFor parental treatment of haemorrhage. The dose can be given for upto 7 days, untill the danger of atony or haemorrhage has passed. Ergonovine should be swallowed or placed under tongue.
500 mcg500 (500)8 hourlyPOFor the treatment of mild secondary postmartum haemorrhage. The dose can be given for 2 to 7 days.

Paedriatic Dosage ( 20 Kg. )

Not Recommended in this Age Group

Neonatal Dosage ( 3 Kg. )

Not recommended in this age group

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, Geriatrics, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Ergometrine should not be used for the induction of labor or during the first stage of labor. Its use should be avoided in patients with eclampsia. In case of any kind of infection or illness check with your doctor before taking Ergonovine since sensitivity to ergonovine's effects may increase.It should be used with caution in patient with impaired pulmonary function, sepsis, renal or hepatic disease and in patients with porphyria. Patient should be advised not to drive or use machines while receiving ergonovine.
In case of any kind of infection or illness check with your doctor before taking Ergonovine since sensitivity to ergonovine's effects may increase.

Storage Conditions

Tab, Inj

Store in a well closed container. Refrigeration is recommended. Protect from Sunlight.

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