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Lactulose is a synthetic derivative of lactose, chemically Lactulose is identified as 4-0-ß-D-Galactopyranosyl-D-fructofuranose. Lactulose is a disaccharide sugar containing one molecule of galactose and one molecule of fructose. It is used in the treatment of hepatic encephalopathy and as a osmotic laxative. Clinical response in the treatment of hepatic encephalopathy is about equal to that of neomycin. It was approved by the FDA in 1976.


Primary Characterstics

Molecular Structure of Lactulose
. It is of Synthetic origin and belongs to Disaccharide Carbohydrate. It belongs to Antimicrobial Agent pharmacological group.The Molecular Weight of Lactulose is 342.30.


Oral absorption of Lactulose is found to be 1% ±1. and metabolism is reported Colon. Renal Excretion accounts for ~ 3 % .


Lactulose is primarily indicated in conditions like Constipation, Hepatic encephalopathy.


Lactulose is contraindicated in conditions like Galactosaemia,GI obstruction.

Drug Interactions

Lactulose is known to interact with other drugs, the details of drug interactions is as follows:


These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interference in Pathology

No data regarding the pathological interferences produced by Lactulose is available.

Side Effects

The severe or irreversible adverse effects of Lactulose, which give rise to further complications include Hypokalemia, Hyponatremia, Hyponatremia.

Lactulose produces potentially life-threatening effects which include Dehydration. which are responsible for the discontinuation of Lactulose therapy.

The signs and symptoms that are produced after the acute overdosage of Lactulose include Diarrhea, Hypernatremia.

The symptomatic adverse reactions produced by Lactulose are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Diarrhea, Abdominal pain, Nausea and vomiting, Bloating, Eructation.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Syrup: 3.35 g, 3.35 gm, 3.35 g/5ml,
Susp: 3.35 g/5ml,
Soln: 3.35 g/5ml,

Multi ingredient

Syrup: 3.35 g, 3.35 gm, 3.35 g/5ml,


Lactulose's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

10 to 20 g15 (15)As recommended.
60 to 100 g80 (80)24 hourlyIn 3 divided doses for hepatic encephalopethy.
15 to 30 ml22 (22.5)As recommended.POAs Required

Paedriatic Dosage ( 20 Kg. )

2.5 to 0 ml1.2 (1.25)As recommended.As required according to age.
335 mg/kg340 (335)12 hourlyOral-

Neonatal Dosage ( 3 Kg. )

209.3 mg/kg210 (209.3)12 hourlyOral

High Risk Groups

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Lactulose should be use with caution in diabetic patients. Avoid use in patients with intestinal obstruction, in patients on low galactose diet. It is relatively contraindicated prior to surgery, especially if the procedure requires the electroquatery during colonoscopy and procto-scopy. The drug should only be used during pregnancy and lactation when clearly needed.

Storage Conditions

Oral Syrup, Rectal Soln

Store in a well closed container, Below 20°C. Protect from Sunlight.

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