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Manufacturer(s) of Noradrenaline (Acid Tartrate) in Pakistan.

Ontech

Noradrenaline (Acid Tartrate)

Overview

Noradrenaline (Acid Tartrate) is a naturally occuring catecholamine, a neurohormone released by the postganglionic adrenergic nerves and some brain neurons. Noradrenaline (Acid Tartrate) is a powerful vasoconstrictor. It causes an increase in blood pressure and used to support blood pressure in acute hypotensive states.

Category:

Primary Characterstics

Noradrenaline (Acid Tartrate) also known as Norepinephrine. . It is of Natural origin and belongs to Catecholamine. It belongs to Alpha adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Drugs used in Shock and Vasoconstrictor pharmacological group.The Molecular Weight of Noradrenaline (Acid Tartrate) is 337.30.
Its pKa is 8.6, 9.8, 12.

Pharmacokinetics

Oral absorption of Noradrenaline (Acid Tartrate) is found to be 60.5% ±9.5. Volume of distribution is found to be 0.09 - 0.40 l/kg and plasma protien binding is 50 %. Presystemic metabolism is noted to be 97% ±2 and metabolism is reported extensive by Liver. Renal Excretion accounts for extensive and plasma half life is 1.75 min.

Indications

Noradrenaline (Acid Tartrate) is primarily indicated in conditions like Acid-related dyspepsia, Cardiac arrest, Hypotension, Shock, and can also be given in adjunctive therapy as an alternative drug of choice in Local anaesthesia, Local anaesthetic.

Contraindications

Noradrenaline (Acid Tartrate) is contraindicated in conditions like Hypertension,Hyperthyroidism,Myocardial infarction,Ischaemic heart disease.

Drug Interactions

Noradrenaline (Acid Tartrate) is known to interact with other drugs, the details of drug interactions is as follows:

DrugDetailsSeverityOnsetManagement
Amitriptyline (HCl)
Amoxapine
Chlorothiazide
Chlorthalidone
Clomipramine (HCl)
Clozapine
Cocaine
Debrisoquine (Sulphate)
Desmopressin (Acetate)
Digoxin
Dopamine (HCl)
Dopexamine (HCl)
Doxepin (HCl)
Ephedrine
GuanethidineGuanethidine work by depleting catecholamines stores from adrenergic nerve endings enhance pharmacologic effect of noradrenaline while decrease its hypotensive effect.ModerateMonitoring of blood pressure and heart rate is must if this combination is used.In hypertensive patients noradrenaline is used with caution.
Halothane
Imipramine (HCl)
Lypressin
Mannitol
MethyldopaMethyldopa enhanced the pressor effects of norepinephrine results in hypertension.ModerateClosely monitor the blood pressure of patient regularly. If hypertension develop, dicontinue the norepinephrine.
Piretanide
Protriptyline (HCl)
Terlipressin
Tolazoline (HCl)
Tramadol (HCl)
Vasopressin
Vecuronium (Br)

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interference in Pathology

No data regarding the pathological interferences produced by Noradrenaline (Acid Tartrate) is available.

Side Effects

The severe or irreversible adverse effects of Noradrenaline (Acid Tartrate), which give rise to further complications include Gangrene, Sloughing, Local necrosis.

Noradrenaline (Acid Tartrate) produces potentially life-threatening effects which include Cerebral hemorrhage, Pulmonary edema, Hypertension. which are responsible for the discontinuation of Noradrenaline (Acid Tartrate) therapy.

The signs and symptoms that are produced after the acute overdosage of Noradrenaline (Acid Tartrate) include Sweating, Headache, Pallor, Severe hypertension, Retrosternal pain, Photophobia.

The symptomatic adverse reactions produced by Noradrenaline (Acid Tartrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Anxiety, Palpitation, Bradycardia.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Inj: 1 mg/ml,

Dosage

Noradrenaline (Acid Tartrate)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

0.114 to 0.171 ug/kg/min0.14 (0.1425)As recommended.IV InfAdjusted according to B.P. response

Paedriatic Dosage ( 20 Kg. )

0.1 to 0.2 ug/kg.min0.15 (0.15)As recommended.IV InfusionMaintenance , As required
0.2 ug/kg.min0.2 (0.2)As recommended.IV InfusionInitial , .As Required

Neonatal Dosage ( 3 Kg. )

0.1 to 0.2 ug/kg.min0.15 (0.15)As recommended.IV InfusionMaintenance , As required
0.2 ug/kg.min0.2 (0.2)As recommended.IV InfusionInitial , .As Required

High Risk Groups

Drug should not be given to Pregnant Mothers, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Infuse noradrenaline into large vein to avoid necrosis & sloughing. Dangerously high B.P may produced with overdoses, so monitor B.P after every two min. from the time of administration until desired B.P is obtained, then after every five min. administration is to be continued. Its use is not a substitute for the replacement of blood, plasma, fluid & electrolytes. .

Storage Conditions

Inj

Store at room temperature. Protect from Sunlight.

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