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Manufacturer(s) of Paracetamol in Pakistan.

AbbottAdamjeeAdcare
AGPAimsAims
AksonAlbroAlfalah Pharma
AlinaAlkemyAlliance
AlsonAmbrosiaAmeer pharma
AmrosArdinAries
ArsonsAsianAskari
AtcoAtlanticAventis
AxisBarrettBatala
BaxterBensonBerlex Lab
BexBiorexBiosynth
BloomBoschBritish
BryonCandidCaraway
CareCCLCirin
CrownCSHDanas
DavisDeltaDelux
Derma techDon valleyDosaco
Dr.RazaDrugEfroze
EG PharmaEliteElko
EnglishEpochEros
EthicalEuroEvergreen
FarmaceuticsFassgenFedro
FerozsonFerroFigs
FlowFozanFriends
FynkGeneraGenix
GenomeGeofmanGlitz
GlobalGlobal brandsGoodman L
Gray'sGSKHamaz
HanselHarmannHassan
HealHealerHelicon
HighnoonHiltonHizat
HoffmanIconIdeal
ImcoIPPIpram
IrzaISISJaens
JafsonJawaJayson
JinnahKCIKohs
KPLKrka-PakLahore Pharma
LawariLawrenceLeama
LexiconLibraLilly
LiskoLotusLowitt
MacquinsMacterMarvi
MassMatrixMax
MBLMederaMediate
MedicaidsMediceenaMedicon
MedicraftMedifineMedipak
MedisearchMedisureMeezab Int.
Mega PharmaMendozaMerck
MianMiracleMunawar
MurfyNabiqasimNafar
NavegalNawabsons LabsNenza
NeoNeutroNexus
NimrallNoa HemisNovamed
NovartisOceanOlive Labs
OrtaPakheimPanacea
ParamountPDHPearl
PharmacarePharmanPharmatec
PharmawisePharmedicPlatinum
PolyfinePopularProgressive Lab
QintarRaazeeRakaposhi
RascoReckittRegent
RekoRemingtonRoche
Roryan PharmaSaaafSafina
SamiSapientSaydon
SayyadSchazooScotmann
SearleSemosShaheen
ShaiganSharexShepherd
ShifaShrooqSpecific
SpencerStandardStandpharm
StanleyStarSurge
Swiss PharmaSYNCHROSyntex
TabrosTagmaTFC PHARMA
TGTreadTrigon
UnexoUnicornUnipharma
UnisonUniversalUsawa
ValorVegaVenus
VisionWahabsonsWebrose
WerrickWilshireWilsons
WoodwardXenonZ-Jans
ZafaZakaZanctok
ZebZephyrZinta

Paracetamol

Overview

Paracetamol is analgesic and antipyretic agent. Paracetamol is the active metabolite of phenacetin, responsible for its analgesic effect. Paracetamol is a weak prostaglandin inhibitor in peripheral tissues and possesses no significant antinflammatory effects. Paracetamol is one of the most important drug used for the treatment of mild to moderate pain when an antinfalmmatory effect is not necessary. Paracetamol is preferred over aspirin as an analgesic/antipyretic for patients in whom aspirin is contraindicated, such as those who have a history of gastric ulcer or a coagulation disorder.

Category:

  • 2 Analgesics, antipyretics, NSAIDs, antigout, and antirheumatics
  • 2.1 Non-opioid analgesics
  • 2.1.2 Paracetamol

Primary Characterstics

Molecular Structure of Paracetamol
Paracetamol also known as Acetaminophen, Acetaminophen. . It is of Synthetic origin and belongs to Aminophenol. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Paracetamol is 151.20.
Its pKa is 9.5.

Pharmacokinetics

Oral absorption of Paracetamol is found to be 96.5% ±1.5. Volume of distribution is found to be 0.9 l/kg and plasma protien binding is < 20%. Presystemic metabolism is noted to be 20% and metabolism is reported hepatic. Renal Excretion accounts for 5% unchanged and plasma half life is 1.5-3.0 hr.

Indications

Contraindications

Paracetamol is contraindicated in conditions like Hypersensitivity.

Drug Interactions

Paracetamol is known to interact with other drugs, the details of drug interactions is as follows:

DrugDetailsSeverityOnsetManagement
Adefovir Dipivoxil
Alcohol
Ascorbic AcidAscorbic acid increases half life of acetaminophen.
Azilisartan MedoxomilAzilisartan when administered with NSAIDS (like paracetamol) can lead to volume depletion
BusulphanMetabolism of Intravenous Busulphan possibly inhibited Paracetamol (caution is advised within 72 hours of Paracetamol).
Carbamazepineplasma concentration of paracetamol may be reduced by anti epileptic such as carbamazepine, phenobarbital , phenytoin or primidoneMinor
Chloramphenicol
Cimetidine (HCl)
Diflunisal
Interferon Alpha
IsoniazidIsoniazid exacerbate the hepatotoxicity of acetaminophen by inducing its CYP450 2E1 metabolism results in toxic metabolites.ModerateCoadministration is considered contraindicated. Cmonitor the patient for hepatotoxicity. Aspirin is considered as safer alternative of paracetamol.
Itopride (HCl)
Metoclopramide (HCl)
Probenecidpretreatment with probenecid can decrease paracetamol clearance and increase plasma half life Minor
Propantheline (Br)Propantheline decreases the gastrointestinal absorption of acetaminophen by reducing gastric motility and delaying gastric emptying.Minor
SulphinpyrazoneSulphinpyrazone increases the hepatotoxicity of paracetamol and decreases its pharmacological effect by accelerating the metabolism of paracetamol.ModerateUse of this combination should be avoided over a prolong period of time. Closely monior for hepatotoxicity.
Warfarin (Na)
Warfarin (Na)Paracetamol potentiate the hypoprothrombinemic effect of warfarinMinorMonitor signs of bleeding.
ZidovudineCombined use of these agents may potentiate the risk of bone marrow suppression and hepatotoxicity.MinorClosely monitor the patient for the development hepatotoxicity and bone marrow toxicity.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interference in Pathology

  • False +ve results for plasma salicylates

Side Effects

The severe or irreversible adverse effects of Paracetamol, which give rise to further complications include Bronchospasm.

Paracetamol produces potentially life-threatening effects which include Blood dyscrasias, Centribular Necrosis, Liver damage. which are responsible for the discontinuation of Paracetamol therapy.

The signs and symptoms that are produced after the acute overdosage of Paracetamol include hypoglycemic coma, Hepatic necrosis, Liver failure, renal tubular necrosis.

The symptomatic adverse reactions produced by Paracetamol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin rashes, GI adverse effects.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Inj: 500 mg, 150 mg/ml,
Inf: 1 g/100ml,
Drops: 12 mg/ml, 80 mg/ml, 100 mg/ml, 60 mg/5ml, 80 mg/0.8ml,
Syrup: 250 mg/5ml,
Susp: 250 mg/ml, 50 mg/5ml, 100 mg/5ml, 120 mg/5ml, 250 mg/5ml,
Elixir: 120 mg/5ml,
Tabs: 125 mg, 160 mg, 200 mg, 250 mg, 300 mg, 325 mg, 500 mg, 650 mg,
Suppositories: 125 mg, 150 mg, 250 mg,

Multi ingredient

Inj: 150 mg/ml,
Drops: 80 mg/0.8ml,
Syrup: 80 mg/5ml, 100 mg/5ml, 120 mg/5ml, 160 mg/5ml, 200 mg/5ml, 250 mg/5ml, 325 mg/5ml,
Susp: 120 mg/5ml,
Elixir: 80 mg/5ml, 325 mg/15ml,
Sachet: 100 mg, 500 mg,
Tabs: 75 mg, 150 mg, 200 mg, 250 mg, 300 mg, 325 mg, 400 mg, 450 mg, 500 mg, 600 mg, 650 mg,
Caps: 300 mg, 500 mg,
Powder: 500 mg/sachet,

Dosage

Paracetamol's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

500 to 1000 mg750 (750)6 hourlyPOMaximum adult dose is 4 g/day in divided doses (i.e. 1g every 6 hourly)

Paedriatic Dosage ( 20 Kg. )

10 to 15 mg/kg/dose12 (12.5)6 hourlyOral

Neonatal Dosage ( 3 Kg. )

12 mg/kg12 (12)6 hourlyOral-

High Risk Groups

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

If sensitivity reaction occurs, discontinue use of paracetamol. If pain persist more than 10 days and arthritic and rheumatic condition affecting children, immediately consult physician. If patient have been diagnosed with liver or kidney impairment, seek medical advice before taking medication. If symptoms persists consult doctor.

Storage Conditions

tab,syr,susp

Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.

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