Pheniramine (Maleate) is antihistamine. Pheniramine (Maleate) is effective in allergic rhinitis and allergic conjunctivitis, mild urticaria, angioedema, and in allergic reactions to blood and plasma in sensitive patients. Pheniramine (Maleate) is widely used as an ingredient in cold and cough preparations.
. It is of Synthetic origin and belongs to Alkylamine. It belongs to H1-antagonist pharmacological group on the basis of mechanism of action and also classified in Antihistamine, Decongestant Combination pharmacological group.The Molecular Weight of Pheniramine (Maleate) is 356.40. Its pKa is 4.2, 9.3.
Oral absorption of Pheniramine (Maleate) is found to be 60.5% ±9.5. Volume of distribution is found to be 230 litre . and metabolism is reported Hepatic. Renal Excretion accounts for 33 - 43 % and plasma half life is 16 - 19 hr.
Pheniramine (Maleate) is primarily indicated in conditions like
Allergy, Angioedema, Angiooedema, Asthma, Conjuctivitis, Dermatitis, Eczema, Hay fever, Perennial rhinitis, Rhinitis, Urticaria, Vasomotor rhinitis, Vertigo.
No data regarding the interactions of Pheniramine (Maleate) was found.
Interference in Pathology
No data regarding the pathological interferences produced by Pheniramine (Maleate) is available.
The severe or irreversible adverse effects of Pheniramine (Maleate), which give rise to further complications include Hallucinations.
The signs and symptoms that are produced after the acute overdosage of Pheniramine (Maleate) include Hyperthermia, Dry mouth, Hallucinations, Palpitations, Dizziness, Muscular weakness, Sedation, Toxic psychosis, Dermatitis.
The symptomatic adverse reactions produced by Pheniramine (Maleate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Tachycardia, Tremors, Constipation, Nervousness, Dry mouth, Blurred vision, Sedation, Muscle weakness, Coordination disturbances, Lassitude, Urinary retention, nervousness.
Click on the appropriate strength of the dosage form to view its available brands.
Single Ingredient Inj: 22.7 mg, 25 mg/ml, 22.7 mg/ml, Syrup: 15 mg/5ml, Tabs: 25 mg, 50 mg, 75 mg, Multi ingredient
Drops: 0.3 %w/v, Eye Drops: 0.3 %w/v, Syrup: 12.5 mg/5ml, 6.25 mg/5ml, Sachet: 13 mg, Tabs: 6.5 mg, Powder: 13 mg/sachet,
Pheniramine (Maleate)'s dosage details are as follows:
25 to 150 mg 88 (87.5) 24 hourly May be given twice daily
12.5 to 25 mg 19 (18.75) 12 hourly PO initial dose, if necessary, may be increased upto 25 mg. Frequency may be increased to 3 times if needed.
Paedriatic Dosage ( 20 Kg. )
0.726 to 1.816 mg/kg 1.3 (1.271) 24 hourly Intra Muscular -
0.75 mg/kg 0.75 (0.75) 8 hourly Oral Dose for 1-3 Yrs of Children
Neonatal Dosage ( 3 Kg. )
1.13 to 2.83 mg/kg 2 (1.98) 24 hourly Intramuscular For above 6 month of child
High Risk Groups
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Warning / Precautions
Pheniramine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any eye problems, high blood pressure, diabetes, thyroid disorder, heart disease, asthma or allergies, especially to sulfites. should not be coadminister in patient who are already on a MAOI therapy because MAOI intensify or prolong the cholinergic effect of antihistamine and therefore pheniramine should be avoided in such conditions.
Store Below 25°C. Protect from Sunlight and Moisture.
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