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Pheniramine (Maleate)


Pheniramine (Maleate) is antihistamine. Pheniramine (Maleate) is effective in allergic rhinitis and allergic conjunctivitis, mild urticaria, angioedema, and in allergic reactions to blood and plasma in sensitive patients. Pheniramine (Maleate) is widely used as an ingredient in cold and cough preparations.


Primary Characterstics

Molecular Structure of Pheniramine (Maleate)
Pheniramine (Maleate) also known as Feniramin, Feniramin, Feniramin. . It is of Synthetic origin and belongs to Alkylamine. It belongs to H1-antagonist pharmacological group on the basis of mechanism of action and also classified in Antihistamine, Decongestant Combination pharmacological group.The Molecular Weight of Pheniramine (Maleate) is 356.40.
Its pKa is 4.2, 9.3.


Oral absorption of Pheniramine (Maleate) is found to be 60.5% ±9.5. Volume of distribution is found to be 230 litre . and metabolism is reported Hepatic. Renal Excretion accounts for 33 - 43 % and plasma half life is 16 - 19 hr.


Pheniramine (Maleate) is primarily indicated in conditions like Allergy, Angioedema, Angiooedema, Asthma, Conjuctivitis, Dermatitis, Eczema, Hay fever, Perennial rhinitis, Rhinitis, Urticaria, Vasomotor rhinitis, Vertigo.


Pheniramine (Maleate) is contraindicated in conditions like Prostatic hypertrophy,Hypersensitivity.

Drug Interactions

No data regarding the interactions of Pheniramine (Maleate) was found.

Interference in Pathology

No data regarding the pathological interferences produced by Pheniramine (Maleate) is available.

Side Effects

The severe or irreversible adverse effects of Pheniramine (Maleate), which give rise to further complications include Hallucinations.

The signs and symptoms that are produced after the acute overdosage of Pheniramine (Maleate) include Hyperthermia, Dry mouth, Hallucinations, Palpitations, Dizziness, Muscular weakness, Sedation, Toxic psychosis, Dermatitis.

The symptomatic adverse reactions produced by Pheniramine (Maleate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Tachycardia, Tremors, Constipation, Nervousness, Dry mouth, Blurred vision, Sedation, Muscle weakness, Coordination disturbances, Lassitude, Urinary retention, nervousness.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Inj: 22.7 mg, 25 mg/ml, 22.7 mg/ml,
Syrup: 15 mg/5ml,
Tabs: 25 mg, 50 mg, 75 mg,

Multi ingredient

Drops: 0.3 %w/v,
Eye Drops: 0.3 %w/v,
Syrup: 12.5 mg/5ml, 6.25 mg/5ml,
Sachet: 13 mg,
Tabs: 6.5 mg,
Powder: 13 mg/sachet,


Pheniramine (Maleate)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

25 to 150 mg88 (87.5)24 hourlyMay be given twice daily
12.5 to 25 mg19 (18.75)12 hourlyPOinitial dose, if necessary, may be increased upto 25 mg. Frequency may be increased to 3 times if needed.

Paedriatic Dosage ( 20 Kg. )

0.726 to 1.816 mg/kg1.3 (1.271)24 hourlyIntra Muscular-
0.75 mg/kg0.75 (0.75)8 hourlyOralDose for 1-3 Yrs of Children

Neonatal Dosage ( 3 Kg. )

1.13 to 2.83 mg/kg2 (1.98)24 hourlyIntramuscularFor above 6 month of child

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Pheniramine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any eye problems, high blood pressure, diabetes, thyroid disorder, heart disease, asthma or allergies, especially to sulfites. should not be coadminister in patient who are already on a MAOI therapy because MAOI intensify or prolong the cholinergic effect of antihistamine and therefore pheniramine should be avoided in such conditions.

Storage Conditions


Store Below 25°C. Protect from Sunlight and Moisture.

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