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Sodium Salicylate

Overview

Sodium Salicylate reduces fever and relieves pain. itused in the symptomatic therapy of gout and in acute rheumatic fever.

Category:

Primary Characterstics

Molecular Structure of Sodium Salicylate
. It is of Synthetic origin and belongs to Hydoroxybenzoate. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Sodium Salicylate is 160.10.
It is weakly acidic drug, 2.53% solution of the drug is isotonic and Its pKa is 2.9, 13.4.

Pharmacokinetics

Oral absorption of Sodium Salicylate is found to be 90% ±10. Volume of distribution is found to be 0.15 - 0.21 l/kg and plasma protien binding is 90 - 95 %. and metabolism is reported Hepatic. Renal Excretion accounts for 80 - 100 % and plasma half life is 2 - 3 hr.

Indications

Sodium Salicylate is primarily indicated in conditions like Fever, Pain, Rheumatoid arthritis.

Contraindications

Sodium Salicylate is contraindicated in conditions like Peptic ulcer,Renal diseases,Gastritis.

Drug Interactions

Sodium Salicylate is known to interact with other drugs, the details of drug interactions is as follows:

DrugDetailsSeverityOnsetManagement
Alcohol
Fludrocortisone (Acetate)
MethotrexateSalicylates interfere with the excretion of methotrexate and may displace it from binding site result in increased toxicity.MajorMonitor patient for signs and symptoms of bone marrow suppression and nephrotoxicity.
Probenecid
Spironolactone
TeniposideConcurrent use may result in potentiation of drug toxicity.
Warfarin (Na)

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interference in Pathology

  • Test for Urinary Glucose, Oestrogens, 17-OH-Corticosteroids, Ketones
  • Serum Uric Acid Test

Side Effects

The severe or irreversible adverse effects of Sodium Salicylate, which give rise to further complications include Hepatotoxicity, Gastric irritation, Mucosal lesions, Worsening of pre-existing heart failure.

Sodium Salicylate produces potentially life-threatening effects which include Hypersensitivity reactions, Reye's syndrome. which are responsible for the discontinuation of Sodium Salicylate therapy.

The signs and symptoms that are produced after the acute overdosage of Sodium Salicylate include Acidosis, Fever, Hyperglycemia, Hypoglycemia, Renal failure, Respiratory alkalosis.

The symptomatic adverse reactions produced by Sodium Salicylate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Tachycardia, Rashes, Hyperventilation, Metabolic acidosis, Respiratory alkalosis, Salicylism.

Available Brands

No Brands Available.

Dosage

Sodium Salicylate's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

4.64 to 8.57 mg/kg6.6 (6.605)4 hourlyPO-
1.74 to 14.29 mg/kg8 (8.015)24 hourlySlow IV-

Paedriatic Dosage ( 20 Kg. )

Not Recommended under 12 Yrs Children

Neonatal Dosage ( 3 Kg. )

Not recommended in this age group

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Sodium salicylate should be used with caution in patients with chronic renal (kidney) insufficiency, gastric ulcer, severe anaemia, patients intolerant to salicylate.

Storage Conditions

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