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Artemether

Overview

Artemether is a derivative of artemisinin (herb found in china). Artemether is used for the treatment of malaria (intermittent or remittent diseases characterized by attacks of chills, fever, and sweating and caused by a parasitic protozoan transferred to the human bloodstream by an anopheles mosquito) in combination with other anti-malarial drugs resistant to conventional drugs.

Category:

Primary Characterstics

Molecular Structure of Artemether
. It is of Natural origin and belongs to Sesquiterpene lactone. It belongs to Antimalarial Agent pharmacological group.The Molecular Weight of Artemether is 298.40.

Pharmacokinetics

Volume of distribution is found to be 20 litre and plasma protien binding is 95.4%. and metabolism is reported liver. Plasma half life is 45 min.

Indications

Interactions

No data regarding the interactions of Artemether was found.

Interference in Pathology

No data regarding the pathological interferences produced by Artemether is available.

Side Effects

The severe or irreversible adverse effects of Artemether, which give rise to further complications include Retinopathy, Neurotoxicity, QT prolongation.

Artemether produces potentially life-threatening effects which include Cardiovascular depression, Cardiopulmonary arrest. which are responsible for the discontinuation of Artemether therapy.

The signs and symptoms that are produced after the acute overdosage of Artemether include Vomiting, Convulsions, Coma, Cardiopulmonary arrest.

The symptomatic adverse reactions produced by Artemether are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Anorexia, Diarrhea, Fever, Insomnia, Tinnitus, Abdominal pain, Sleep disturbancesX, Rashes, Urticaria, Pruritus, Itching, Sleep disturbance, Hypotension, Elevation of liver enzymes, Transient low fever, Abnormal gait, parasthesia, Decreased hearing.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Inj: 40 mg/ml, 80 mg/ml,
Inj-IM: 80 mg,
Susp: 15 mg/5ml, 40 mg/5ml,
Tabs: 20 mg, 40 mg, 60 mg, 80 mg,
Caps: 20 mg, 40 mg, 80 mg,
Soft Caps: 40 mg,

Multi ingredient

Inj: 80 mg/ml,
Syrup: 15 mg/5ml,
Susp: 15 mg, 15 mg/5ml, 30 mg/5ml, 90 mg/5ml,
Dry Susp: 15 mg/5ml, 30 mg/5ml,
Cream: 0.08 %w/w,
Tabs: 20 mg, 40 mg, 80 mg, 120 mg, 240 mg,
Tabs DS: 40 mg,
Caps: 20 mg, 40 mg, 80 mg,

Manufacturer(s) of Artemether
  • Adamjee

  • Advanced

  • AGP

  • Aims

  • Alliance

  • Alson

  • Amarant

  • Ambrosia

  • Amros

  • Amson

  • Aptcure

  • Ardin

  • Aries

  • Atco

  • Barrett

  • Benson

  • Biogen

  • Biolabs

  • Biorex

  • Bloom

  • Bosch

  • British

  • Brookes

  • Candid

  • Caraway

  • CCL

  • Cirin

  • Crest

  • Crown

  • CSH

  • Danas

  • Delta

  • Dyson R L

  • Elko

  • English

  • Envoy

  • Epla

  • Epoch

  • Eros

  • Everest

  • Evergreen

  • Farm

  • Farmaceutics

  • Fassgen

  • Fedro

  • Ferozson

  • Florence

  • FOCUS & RULZ

  • Fozan

  • Friends

  • Fynk

  • Genera

  • Genix

  • Genome

  • Geofman Impex

  • Getz

  • Glitz

  • Global

  • Goodman L

  • Gray's

  • Hamaz

  • Hansel

  • Heal

  • Healer

  • Helix

  • High-Q

  • Highnoon

  • Hilton

  • Himont Pharma

  • Hisun

  • Hoover

  • Hygeia

  • Imco

  • Indus

  • ISIS

  • Jaens

  • Jinnah

  • KCI

  • Lawari

  • LEADS

  • Lexicon

  • Linear

  • Lotus

  • Lowitt

  • Macter

  • Makson

  • Martin

  • MBL

  • MCOLSON

  • Medera

  • Mediate

  • Medicaids

  • Medicon

  • Medicraft

  • Medicure

  • Medimarkers

  • MEDISAVE

  • Medisure

  • Meditech

  • Medizan Lab

  • Medley

  • Meezab Int.

  • Mendoza

  • Miracle

  • MKB

  • Nabiqasim

  • Navegal

  • Nenza

  • Neo

  • Neutro

  • Nexus

  • Nimrall

  • Noa Hemis

  • Novartis

  • Obs

  • Olive

  • Opal

  • Ottoman

  • Pak

  • Panacea

  • Paramount

  • Pearl Pharma

  • Pfizer

  • Pharmacare

  • Pharman

  • Pharmedic

  • Pharmevo

  • Pharmix

  • Platinum

  • Polyfine

  • Popular

  • PPP

  • Prays

  • Pulse

  • Raazee

  • Rakaposhi

  • Rasco

  • Ray

  • Regent

  • Rogen

  • Roryan Pharma

  • Rotex

  • S.J.& G

  • Saaaf

  • Sami

  • Sapient

  • Saydon

  • Sayyad

  • Schazoo

  • Searle

  • Semos

  • Shaheen

  • Shawan

  • Shazal

  • Shrooq

  • Siza

  • SPL

  • Standard

  • Star

  • Surge

  • Swan

  • Swiss Pharma

  • Tabros

  • TG

  • TRISON

  • Unimark

  • Unison

  • Universal

  • Usawa

  • Valor

  • Vega

  • Weather

  • Webrose

  • Well

  • Wellborne

  • Welmark

  • Welmed

  • Welwrd

  • Wilshire

  • Winbrain

  • Winilton

  • Wise

  • WnsFeild

  • Woodward

  • Z-Jans

  • Zafa

  • Zaka

  • Zephyr

Dosage

Artemether's dosage details are as follows: No data regarding the Paedriatic dosage details of Artemether is available.
Dose Single Dose Frequency Route Instructions
Adult Dosage

160.000 mg

160 (160)

24 hourly

PO,IM

Initial

80.000 mg

80 (80)

24 hourly

PO.IM

Maintenance, As Required

Paedriatic Dosage ( 20 Kg. )

3.200 mg/kg

3.2 (3.2)

12 hourly

Intra Muscular

For 3 Days

Neonatal Dosage ( 3 Kg. )

High Risk Groups

Drug should not be given to Pregnant Mothers, and Cardiac / Hypertensive Patients.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Care should be taken when using to treat the women being pregnant with in three months or patients with severe vomiting. Administeration of Artemether with drugs that are metabolized by Cytochrome Enzyme CYP 2D6 like Flecainide,Metoprolol,Imipramine,Amitryptaline,Clomipramine should be avoided and artemether should also be avoided with drugs that prolong QT interval

Storage Conditions

Tab

Store in a well closed container, at room temperature, Below 30°C. Protect from Moisture.

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