Severity N/A
Cimetidine (HCl) Interaction of Cimetidine (HCl) with Bisoprolol (Fumarate)
Clonidine (HCl) Interaction of Clonidine (HCl) with Bisoprolol (Fumarate)
Indomethacin Interaction of Indomethacin with Bisoprolol (Fumarate)
Details: NSAIDs antagonizes antihypertensive effects of beta-blockers.
Interaction of Adrenaline with Bisoprolol (Fumarate)
Details: Severe hypertension when beta-blockers given with Adrenaline.
Interaction of Verapamil (HCl) with Bisoprolol (Fumarate)
Details: Severe hypotension and heart failure when beta-blockers given with Verapamil.
Interaction of Diltiazem (HCl) with Bisoprolol (Fumarate)
Details: Severe hypotension and heart failure when beta-blockers given with Diltiazem.
Interaction of VORICONAZOLE with Bisoprolol (Fumarate)
Details: Voriconazole may increase the serum concentration of bisoprolol by decreasing its metabolism
Management: Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or if doses are changed.
Interaction of Indacaterol with Bisoprolol (Fumarate)
Details: Beta-blockers may exacerbate bronchospasms in patients with COPD
Management: monitor closely
Major
Amiodarone (HCl) Interaction of Amiodarone (HCl) with Bisoprolol (Fumarate)
Details: Amiodarone may enhance the bradycardic effect of Bisoprolol. Possibly to the point of cardiac arrest.
Management: Monitor increased signs and symptoms of bradycardia with Bisoprolol (possibly to the point of cardiac arrest) if amiodarone is initiated/dose increased, or decreased effects if amiodarone is discontinued/dose decreased. Ophthalmic beta-blockers are likely of little concern.
Interaction of Theophylline with Bisoprolol (Fumarate)
Details: Bisoprolol reduces the CYP450 hepatic metabolism of theophylline and its serum levels may be increased.
Management: Closely monitored the increased serum level of theophylline and decreased bronchodilatory effectiveness.
Moderate
Naproxen Interaction of Naproxen with Bisoprolol (Fumarate)
Details: Naproxen through renal prostaglandin synthesis inhibition reduces the antihypertensive activity of bisoprolol.
Management: Altered antihypertensive response is monitored whenever naproxen is introduced or discontinued in treatment.
Interaction of Nifedipine with Bisoprolol (Fumarate)
Details: Coadministration additively reduces in heart rate, cardiac conduction and cardiac contractility. While this combination is useful in congestive heart failure, severe hypotension and angina.
Management: Dose of both agents must be adjusted and close clinical monitoring of hemodynamic response must be recommended.
Interaction of Rifampicin with Bisoprolol (Fumarate)
Details: Metabolism of Bisoprolol accelerated by Rifampicin (plasma concentration significantly reduced)
Interaction of Digoxin with Bisoprolol (Fumarate)
Details: Bisoprolol may potentiate bradycardia due to Digoxin.
Management: Monitor for increased bradycardia if these two agents are used concomitantly. Ophthalmic beta-blockers are likely of little concern.