Severity N/A
Cimetidine (HCl) Interaction of Cimetidine (HCl) with Bisoprolol (Fumarate)
Clonidine (HCl) Interaction of Clonidine (HCl) with Bisoprolol (Fumarate)
Indomethacin Interaction of Indomethacin with Bisoprolol (Fumarate)
Details: NSAIDs antagonizes antihypertensive effects of beta-blockers.
Adrenaline Interaction of Adrenaline with Bisoprolol (Fumarate)
Details: Severe hypertension when beta-blockers given with Adrenaline.
Verapamil (HCl) Interaction of Verapamil (HCl) with Bisoprolol (Fumarate)
Details: Severe hypotension and heart failure when beta-blockers given with Verapamil.
Diltiazem (HCl) Interaction of Diltiazem (HCl) with Bisoprolol (Fumarate)
Details: Severe hypotension and heart failure when beta-blockers given with Diltiazem.
VORICONAZOLE Interaction of VORICONAZOLE with Bisoprolol (Fumarate)
Details: Voriconazole may increase the serum concentration of bisoprolol by decreasing its metabolism
Management: Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or if doses are changed.
Indacaterol Interaction of Indacaterol with Bisoprolol (Fumarate)
Details: Beta-blockers may exacerbate bronchospasms in patients with COPD
Management: monitor closely
Major
Amiodarone (HCl) Interaction of Amiodarone (HCl) with Bisoprolol (Fumarate)
Details: Amiodarone may enhance the bradycardic effect of Bisoprolol. Possibly to the point of cardiac arrest.
Management: Monitor increased signs and symptoms of bradycardia with Bisoprolol (possibly to the point of cardiac arrest) if amiodarone is initiated/dose increased, or decreased effects if amiodarone is discontinued/dose decreased. Ophthalmic beta-blockers are likely of little concern.
Theophylline Interaction of Theophylline with Bisoprolol (Fumarate)
Details: Bisoprolol reduces the CYP450 hepatic metabolism of theophylline and its serum levels may be increased.
Management: Closely monitored the increased serum level of theophylline and decreased bronchodilatory effectiveness.
Moderate
Naproxen Interaction of Naproxen with Bisoprolol (Fumarate)
Details: Naproxen through renal prostaglandin synthesis inhibition reduces the antihypertensive activity of bisoprolol.
Management: Altered antihypertensive response is monitored whenever naproxen is introduced or discontinued in treatment.
Nifedipine Interaction of Nifedipine with Bisoprolol (Fumarate)
Details: Coadministration additively reduces in heart rate, cardiac conduction and cardiac contractility. While this combination is useful in congestive heart failure, severe hypotension and angina.
Management: Dose of both agents must be adjusted and close clinical monitoring of hemodynamic response must be recommended.
Rifampicin Interaction of Rifampicin with Bisoprolol (Fumarate)
Details: Metabolism of Bisoprolol accelerated by Rifampicin (plasma concentration significantly reduced)
Digoxin Interaction of Digoxin with Bisoprolol (Fumarate)
Details: Bisoprolol may potentiate bradycardia due to Digoxin.
Management: Monitor for increased bradycardia if these two agents are used concomitantly. Ophthalmic beta-blockers are likely of little concern.