Valsartan
Overview
Valsartan belongs to a new and rapidly growing group of drugs known as angiotensin receptor antagonists. itsimilar to losartan. Valsartan antagonizes angiotensin II at the AT1 receptor subtype. Two angiotensin II receptors, AT1 and AT 2, have been identified. Angiotensin II is the primary vasoactive hormone of the renin-angiontensin system and plays an important role in the pathophysiology of hypertension and congestive heart failure. Valsartan is currently approved as an oral antihypertensive agent, either alone or in combination with other antihypertensive agents. Valsartan reduces left ventricular hypertrophy, although the clinical benefValsartan associated with reducing LV hypertrophy is not well established. Unlike losartan, Valsartan has no effect on serum uric acid. Valsartan was FDA approved for the treatment of hypertension on 23rd december 1996.
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Drug Interactions
Valsartan is known to interact with other drugs, the details of drug interactions is as follows:
Severity N/A
Lacosamide Interaction of Lacosamide with Valsartan
Doxorubicin (HCl) Interaction of Doxorubicin (HCl) with Valsartan
Potassium Glycerophosphate Interaction of Potassium Glycerophosphate with Valsartan
Details: Concurrent use may cause too much potassium in the blood.
These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
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Side Effects
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Dosage
Valsartan's dosage details are as follows:
Dose
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Single Dose
|
Frequency
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Route
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Instructions
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Adult Dosage
|
80 to 160 mg | 120 (120) | 24 hourly | PO | |
Paedriatic Dosage (20kg)
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| | | | Not recommended in this age group |
Neonatal Dosage (3kg)
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No data regarding the neonatal dosage details of Valsartan is available. |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Valsartan
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