Valsartan

Overview

Valsartan belongs to a new and rapidly growing group of drugs known as angiotensin receptor antagonists. itsimilar to losartan. Valsartan antagonizes angiotensin II at the AT1 receptor subtype. Two angiotensin II receptors, AT1 and AT 2, have been identified. Angiotensin II is the primary vasoactive hormone of the renin-angiontensin system and plays an important role in the pathophysiology of hypertension and congestive heart failure. Valsartan is currently approved as an oral antihypertensive agent, either alone or in combination with other antihypertensive agents. Valsartan reduces left ventricular hypertrophy, although the clinical benefValsartan associated with reducing LV hypertrophy is not well established. Unlike losartan, Valsartan has no effect on serum uric acid. Valsartan was FDA approved for the treatment of hypertension on 23rd december 1996.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

Valsartan is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Lacosamide

Interaction of Lacosamide with Valsartan

Doxorubicin (HCl)

Interaction of Doxorubicin (HCl) with Valsartan

Potassium Glycerophosphate

Interaction of Potassium Glycerophosphate with Valsartan

Details: Concurrent use may cause too much potassium in the blood.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

Valsartan's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

80 to 160 mg120 (120)24 hourlyPO

Paedriatic Dosage (20kg)

Not recommended in this age group

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Valsartan is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Valsartan

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