Cabergoline

Overview

Cabergotune is ergot derivatives is a dopamine D2-agonist with action and uses similar to bromocriptine. Cabergoline is used after pregnancy to suppress unwanted breast milk secretion and to facilitate conception when infertility is associated with high prolactin level. It may also be used in parkinson's disease, prolactin-producing tumors and to adjust various hormone levels in certain diseases (ovarian diseases).

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

Cabergoline is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Alcohol

Interaction of Alcohol with Cabergoline

Levodopa

Interaction of Levodopa with Cabergoline

Octreotide (Acetate)

Interaction of Octreotide (Acetate) with Cabergoline

Metoclopramide (HCl)

Interaction of Metoclopramide (HCl) with Cabergoline

Details: Hypoprolactinemic effect of Cabergoline possibly antagonized by Metoclopramide.
Domperidone

Interaction of Domperidone with Cabergoline

Details: Hypoprolactinemic and antiparkinsonian effects of Cabergoline possibly antagonized by Domperidone.
Erythromycin

Interaction of Erythromycin with Cabergoline

Details: Plasma concentration of cabergoline increased by Erythromycin (increased risk of toxicity).
Methyldopa

Interaction of Methyldopa with Cabergoline

Details: Antiparkinsonian effect of Cabergoline possibly antagonized by Methyldopa.
Clozapine

Interaction of Clozapine with Cabergoline

Details: Hypoprolactinemic and antiparkinsonian effects of Cabergoline possibly antagonized by antipsychotics (e.g Clozapine).
VORICONAZOLE

Interaction of VORICONAZOLE with Cabergoline

Details: Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel.
Management: Avoid concomitant therapy

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

Cabergoline's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage
POprevention of lactation 1mg as single dose: suppression of established lactation 250 mcg every 12 hrs for 2 days
POHyperprolacdinaemic disorders: (0.25-2 mg weekly)
1 to 1 mg/day1 (1)As recommended.POFor parkinson''s disease: Increase by increments of 0.5-1 mg at 7-14 day interval. Man 3 mg/day.

Paedriatic Dosage (20kg)
Not Recommended in this Age Group

Neonatal Dosage (3kg)
Not recommended in this age group

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Cabergoline

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Manufacturers of Cabergoline in Pakistan

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