Eflornithine
Overview
Eflornithine (HCl) is an antiprotozoal agent. Eflornithine (HCl) is used in the treatment of African trypanosomiasis and is effective in early and more importantly in late stages of this disease when there is CNS involvement. It acts as an irreversible inhibitor of ornithine decarboxylase, the rate-limiting enzyme in the biosynthesis; trypanosomas are more susceptible yo the effect of eflornithine. It also has activity against Pneuocystis carinii.
Primary Characterstics
Indications
Back to top
Pharmacokinetics
Back to top
Contraindications
Back to top
Back to top
Side Effects
Back to top
Dosage
Eflornithine's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 100 mg/kg | 100 (100) | As recommended. | IV | every 6hr for 7-14 day. |
Paedriatic Dosage (20kg)
|
| No data regarding the Paedriatic dosage details of Eflornithine is available. |
Neonatal Dosage (3kg)
|
| No data regarding the neonatal dosage details of Eflornithine is available. |
High Risk Groups
Back to top
Warning / Precautions
Back to top
Storage Conditions
Back to top
Interference in Pathology
Back to top
Brands / Trade Names of
Eflornithine
Back to top
Previous Drug Generic - Next Drug Generic