Telithromycin

Overview

A derivative of erythromycin, antibacterial spectrum of telithromycin is similar to that of macrolides and it is also active against penicillin- and erythromycin-resistant Streptococcus pneumoniae. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed .It is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

Categories

  • 6 Anti-infective drugs

Primary Characterstics

Indications

Telithromycin is primarily indicated in conditions like Prevention of relapse in duodenal ulcer, Sedation in intensive care, Severe or recurrent duodenal and gastric ulcertion, Sinusitis, Tonsillitis.

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Pharmacokinetics

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Contraindications

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Drug Interactions

Telithromycin is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Clorazepate (K)

Interaction of Clorazepate (K) with Telithromycin

Phenytoin (Na)

Interaction of Phenytoin (Na) with Telithromycin

Details: Phenytoin (Na) is likely to result in subtherapeutic levels of telithromycin and loss of effect.
Carbamazepine

Interaction of Carbamazepine with Telithromycin

Details: Carbamazepine is likely to result in subtherapeutic levels of telithromycin and loss of effect.
Phenobarbitone

Interaction of Phenobarbitone with Telithromycin

Details: Phenobarbitone is likely to result in subtherapeutic levels of telithromycin and loss of effect.
Digoxin

Interaction of Digoxin with Telithromycin

Details: Monitoring of digoxin side effects or serum levels should be considered during concomitant administration of digoxin and Teicoplanin.
Cisapride

Interaction of Cisapride with Telithromycin

Details: The use of Teicoplanin is contraindicated with cisapride.
Pimozide

Interaction of Pimozide with Telithromycin

Details: There is a potential risk of increased pimozide plasma levels by inhibition of CYP 3A4 pathways by Teicoplanin.
Management: Concurrent use is contraindicated.
Simvastatin

Interaction of Simvastatin with Telithromycin

Details: Simvastatin levels were increased by Teicoplanin when used concurrently.
Sunitinib

Interaction of Sunitinib with Telithromycin

Details: May increases sunitinib concentrations.
Erlotinib

Interaction of Erlotinib with Telithromycin

Details: This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Vemurafenib

Interaction of Vemurafenib with Telithromycin

Details: Telithromycin inhibits P-gp, glucuronidation and CYP3A4, and increases plasma concentration of Vemurafenib.
VORICONAZOLE

Interaction of VORICONAZOLE with Telithromycin

Details: Voriconazole may increase the serum concentration of telithromycin by decreasing its metabolism.
Management: Monitor for changes in the therapeutic and adverse effects
Ibrutinib

Interaction of Ibrutinib with Telithromycin

Details: increased exposure of ibrutinib
Management: co-administration should be avoided
Simeprevir

Interaction of Simeprevir with Telithromycin

Details: co- administration increased plasma concentrations of simeprevir
Management: not recommended to co-administered

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

Telithromycin's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage
800 mg800 (800)24 hourlyPOFor 5 days for Beta-hemolytic streptococcal pharyngitis or tonsilitis.
800 mg800 (800)24 hourlyPOFor 7-10 days in community-acquired pneumonia.
800 mg800 (800)24 hourlyPOFor 5 days for sinusitis or exacerbation of chronic bronchitis.

Paedriatic Dosage (20kg)
No data regarding the Paedriatic dosage details of Telithromycin is available.

Neonatal Dosage (3kg)
No data regarding the neonatal dosage details of Telithromycin is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Telithromycin

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Manufacturers of Telithromycin in Pakistan

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