Disodium Pamidronate

Overview

Disodium Pamidronate is a bisphosphonate, inhibits bone resorption and thus reduces bone turn over. Disodium Pamidronate is used in the treatment of bone disorders in which excessive bone resorption is a problem, such as paget`s disease of bone and osteoporosis. Disodium Pamidronate is also used as an adjunct insevere hypercalcaemic conditions especially associated with malignancies.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

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Side Effects

The symptomatic adverse reactions produced by Disodium Pamidronate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Anorexia, Diarrhea, Fever, Myalgia, Constipation, Insomnia, Abdominal pain, Rashes, Confusion, Pruritus, Lethargy, Hallucination, Dyspepsia, Malaise, Hypotension, Somnolence, Flushing, Arthralgia, Nausea and vomiting, Muscle cramps, Influenza like syndrome, Agitation, Conjunctivitis, Rigors, Seizures, Transient rise in body temperature, Transient bone pain, Local reaction at injection site, Confusion, dizziness, dyspepsia, Thrombophili.

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Dosage

Bisoprolol (Fumarate)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

30 mg30 (30)24 hourlyIVFor paget disease: administered as a 4-hour infusion on 3 consecutive days for a total dose of 90 mg.
60 to 90 mg75 (75)As recommended.IVModerate hypercalcemia: Given as a SINGLE-DOSE, intravenous infusion over 2 to 24 hours.

Paedriatic Dosage (20kg)

No data regarding the Paedriatic dosage details of Bisoprolol (Fumarate) is available.

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Bisoprolol (Fumarate) is available.

High Risk Groups

Drug should not be given to Paediatrics, and Pregnant Mothers.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

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Warning / Precautions

Disodium Pamidronate should be used with caution in patients with cardiac desease with renal impairment---monitor renal function in renal disease or predisposition to renal impairment (e.g in multiple myeloma or tumor induced hypercalcaemia); cardiac disease (especially in elderly); previous thyroid surgery (risk of hypocalcaemia); monitor serum electrolyte, calcium and phosphate---possibility of convulsions due to electrolyte changes; avoid concurrent use with other bisphosphonate. DRIVING: Patients should be warned against driving or operating machinery immediately after treatment (somnolence or dizziness may occur)

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Storage Conditions

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Interference in Pathology

  • Abnormal LFTs

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Brands / Trade Names of Bisoprolol (Fumarate)

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Manufacturers of Disodium Pamidronate in Pakistan

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