Side Effects
The symptomatic adverse reactions produced by Disodium Pamidronate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Anorexia, Diarrhea, Fever, Myalgia, Constipation, Insomnia, Abdominal pain, Rashes, Confusion, Pruritus, Lethargy, Hallucination, Dyspepsia, Malaise, Hypotension, Somnolence, Flushing, Arthralgia, Nausea and vomiting, Muscle cramps, Influenza like syndrome, Agitation, Conjunctivitis, Rigors, Seizures, Transient rise in body temperature, Transient bone pain, Local reaction at injection site, Confusion, dizziness, dyspepsia, Thrombophili.
High Risk Groups
Drug should not be given to Paediatrics, and Pregnant Mothers.
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Warning / Precautions
Disodium Pamidronate should be used with caution in patients with cardiac desease with renal impairment---monitor renal function in renal disease or predisposition to renal impairment (e.g in multiple myeloma or tumor induced hypercalcaemia); cardiac disease (especially in elderly); previous thyroid surgery (risk of hypocalcaemia); monitor serum electrolyte, calcium and phosphate---possibility of convulsions due to electrolyte changes; avoid concurrent use with other bisphosphonate. DRIVING: Patients should be warned against driving or operating machinery immediately after treatment (somnolence or dizziness may occur)