Cyclophosphamide
Overview
Cyclophosphamide is a cytotoxic alkylating agent of the nitrogen mustard group. Cyclophosphamide is anticancerous or antineoplastic drug. All alkylating agent have or can form an alkyl group that becomes covalently bound to cellular constituents. Cyclophosphamide is effective in the treatment of different cancers to slow or stop the growth of abnormal or cancerous cells. Cyclophosphamide is used in combination with different anticancerous drugs to obtain the excellent therapeutic effects and to minimize side effects or toxicities. It also has immunosuppressant properties and Cyclophosphamide is the most potent immunosuppressive agent that has been synthesized.
Categories
- 2 Analgesics, antipyretics, NSAIDs, antigout, and antirheumatics
- 8 Antineoplastics, immunomodulators and drugs used in palliative care
Primary Characterstics
Indications
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Pharmacokinetics
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Side Effects
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Dosage
Cyclophosphamide's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 2 to 6 mg/kg | 4 (4) | As recommended. | IV | per week. |
| 2 to 6 mg/ kg | 4 (4) | As recommended. | PO | In div.doses per week. |
Paedriatic Dosage (20kg)
|
| 1250 to 2330 mg/sq.meter | 1800 (1790) | As recommended. | Intra Venous | Per Month. |
| 730 mg/sq.meter | 1300 (1338) | As recommended. | Oral | On Days 1-5 every month |
Neonatal Dosage (3kg)
|
| No data regarding the neonatal dosage details of Cyclophosphamide is available. |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Cyclophosphamide
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Manufacturers of
Cyclophosphamide
in Pakistan
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