Severity N/A
Chloramphenicol Interaction of Chloramphenicol with Ciprofloxacin
Sucralfate Interaction of Sucralfate with Ciprofloxacin
Calcium Carbonate Interaction of Calcium Carbonate with Ciprofloxacin
Details: binds with drugs or increase pH that effects drug solubility
Management: antacid should not be given within two hours of the dose of these drugs
Interaction of Multiple Vitamins with Ciprofloxacin
Details: Concurrent use may decrease the absorption of Ciprofloxacin.
Management: Separate your doses of Ciprofloxacin as far as possible from doses of multi vitamins.
Interaction of Rutin (Vitamin P) with Ciprofloxacin
Details: Rutin may competitively inhibit action of Ciprofloxacin.
Interaction of Magnesium Oxides and Hydroxides with Ciprofloxacin
Details: Magnesium hydroxides and aluminium hydroxide antacids, iron, calcium, zinc containing products impair absorption of ciprofloxacin.
Interaction of Rifampicin with Ciprofloxacin
Details: Rifampin induces the metabolism of ciprofloxacin.
Interaction of Insulin Lispro Protamine with Ciprofloxacin
Sevelamer HCl Interaction of Sevelamer HCl with Ciprofloxacin
Details: sevelamer hydrochloride decreased the bioavailability of ciprofloxacin by approximately 50%.
Management: Should not be taken simultaneously with ciprofloxacin
Interaction of Pomalidomide with Ciprofloxacin
Details: Pomalidomide exposure is increased co-administered with ciprofloxacin
Management: Avoid co-administration, if medically necessary Pomalidomide dose should be reduced
by 50%.
Interaction of Ibrutinib with Ciprofloxacin
Details: may increase the AUC of ibrutinib 5-9 fold.
Management: co-administration should be avoided
Major
Theophylline Interaction of Theophylline with Ciprofloxacin
Details: Ciprofloxacin enhances the serum level of theophylline by inhibiting its metabolism and by reducing its clearence upto 65% may result in increased risk of toxicity. Concomitant use of theohylline with interavenous ciprofloxacin may results cardiac arrest, seizure,status epilepticus and respiratory failure.
Management: Concomitant use should be avoided. Closely monitor the pharmacologic response and serum level of theophylline whenever start, discontinue or change the dose of ciprfloxacin.Patient should notify the symptoms of theophylline toxicity.
Interaction of Warfarin (Na) with Ciprofloxacin
Details: Ciprofloxacin potentiate the hypoprothrombinemic effect of warfarin by inhibiting its metabolism and depleting certain clotting factors due to suppression of vitamin-k producing intestinal flora.
Management: INR should be checked frequently and dose of warfarin should be adjusted whenever start or discontinue quinolone therapy. Patient should report any sign of bleeding to doctor.
Moderate
Methotrexate Interaction of Methotrexate with Ciprofloxacin
Details: Ciprofloxacin increases the plasma concentration of methotrexate by competitively inhibiting renal tubular secretion of methotrexate result in severe toxicity.
Management: Concomitant use of these drugs considered contraindicated. Closely monitor for altered pharmacologic effects. Adjust the dose if necessary.
Interaction of Clozapine with Ciprofloxacin
Details: Coadministration increases the plasma concentration of clozapine by inhibiting CYP450 1A2 responsible for metabolic clearance of clozapine.
Management: Pharmacological response and plasma clozapine concentration should be monitored closely.
Interaction of Cyclosporin A with Ciprofloxacin
Details: Ciprofloxacin increases the serum concentration of cyclosporin. The risk of cyclosporine induced neurotoxicity and nephrotoxicity may also be increased.
Management: Cyclosporine levels and renal function must be closely monitored.
Interaction of Caffeine with Ciprofloxacin
Details: Coadministration inhibit the metabolism of caffeine thus increasing its plasma concentration and pharmacological effect.Ciprofloxacin increases caffeine AUC by 50% to over 100% and reduces its clearance upto 50%.
Management: Caffeine intake should be avoided during treatment that may increase the risk of adverse effects like tremor,insomnia,tachycardia and blood pressure.
Interaction of Naproxen with Ciprofloxacin
Details: Piperazine ring of ciprofloxacin inhibits the binding of GABA to brain receptors and naproxen synergistically add to this effect thus increase the risk of CNS stimulation and convulsion.
Management: Close monitoring of CNS stimulation is advised.
Interaction of Phenytoin (Na) with Ciprofloxacin
Details: Ciprofloxacin may either increase or decrease the plasma concentration of phenytoin, thus increasing the risk of phenytoin toxicity or seizure.
Management: Closely monitor the plasma concentration of phenytoin whenever start or discontinue ciprofloxacin. Adjust the dose of phenytoin accordingly.
Interaction of Mangnese Glycerophosphate with Ciprofloxacin
Details: Mangnese decreases effectiveness of Quinolone antibiotics
Management: Take manganese supplements at least one hour after antibiotics.