Desmopressin (Acetate)

Overview

Desmopressin is a long acting synthetic analog of 8-arginine vasopressin. It has an anti-diuretic to pressor ratio 4000 times than that of vasopressin, which is the pressor and antidiuretic principle of posterior lobe of pituitary gland. Desmopressin (Acetate) is used intranasally in diabetes insipidus and nocturnal enuresis.

Categories

• 10 Drugs affecting the blood
  • 10.3 Antihemorrhagics/Antihemophilics

• 18 Hormones and other endocrine drugs and contraceptives
  • 18.12 Drugs used in diabetes insipidus

Page headings

Primary Characterstics

Indications

Desmopressin (Acetate) is primarily indicated in conditions like Diabetes insipidus, Haemophilia, Nocturnal enuresis, Post-lumbar puncture headache, Primary nocturnal enuresis, Renal function testing, Von willebrand's disease, and can also be given in adjunctive therapy as an alternative drug of choice in Nocturia associated with multiple sclerosis, Polydipsia.

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Desmopressin (Acetate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
10 to 40 ug	25 (25)	As recommended.	Intra Nasal	Single dose or may be given in 2-3 divided doses.
300 to 400 ng/kg	350 (350)	As recommended.	IV infusion	Given over 15 to 30 min for haemophillia or type I von Willebrand's disease and also given for testing of fibirinolytic response
200 to 400 ug	300 (300)	As recommended.	Orally	For primary nocturnal enuresis.
100 ug	100 (100)	8 hourly	Orally	As in initial dose for cranial diabetes insipidus.
0.1 to 0.2 mg	0.15 (0.15)	8 hourly	PO
Paedriatic Dosage (20kg)
0.04 ug/kg	0.04 (0.04)	As recommended.	Intra Muscular	Single dose recommended in diabetes incipidus
0.04 ug/kg	0.04 (0.04)	As recommended.	Intra Venous	Single dose recommended in diabetes incipidus
2.5 to 20 ug	11 (11.25)	12 hourly	Nasal
10 ug	10 (10)	8 hourly	Oral	For 1 month to 2years. Given as initial dose and adjusted according to response.
50 ug	50 (50)	8 hourly	Orally	for 2 to 12 year.
100 ug	100 (100)	8 hourly	Orally	for 12 to 18 years
Neonatal Dosage (3kg)
No data regarding the neonatal dosage details of Desmopressin (Acetate) is available.

High Risk Groups

Warning / Precautions

Storage Conditions

Nasal Spray, Inj

Store at room temperature, Below 25°C or in refrigerator. Do not Freeze. Use within 3 weeks if kept at room temperature.

Interference in Pathology

Brands / Trade Names of Desmopressin (Acetate)

Manufacturers of Desmopressin (Acetate) in Pakistan

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