Desmopressin (Acetate)

Overview

Desmopressin is a long acting synthetic analog of 8-arginine vasopressin. It has an anti-diuretic to pressor ratio 4000 times than that of vasopressin, which is the pressor and antidiuretic principle of posterior lobe of pituitary gland. Desmopressin (Acetate) is used intranasally in diabetes insipidus and nocturnal enuresis.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

Desmopressin (Acetate) is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Noradrenaline (Acid Tartrate)

Interaction of Noradrenaline (Acid Tartrate) with Desmopressin (Acetate)

Lithium

Interaction of Lithium with Desmopressin (Acetate)

Heparin (Na) and Heparin (Cl)

Interaction of Heparin (Na) and Heparin (Cl) with Desmopressin (Acetate)

Fludrocortisone (Acetate)

Interaction of Fludrocortisone (Acetate) with Desmopressin (Acetate)

Alcohol

Interaction of Alcohol with Desmopressin (Acetate)

Demeclocycline (HCl)

Interaction of Demeclocycline (HCl) with Desmopressin (Acetate)

Clofibrate

Interaction of Clofibrate with Desmopressin (Acetate)

Cimetidine (HCl)

Interaction of Cimetidine (HCl) with Desmopressin (Acetate)

Chlorpropamide

Interaction of Chlorpropamide with Desmopressin (Acetate)

Carbamazepine

Interaction of Carbamazepine with Desmopressin (Acetate)

Indomethacin

Interaction of Indomethacin with Desmopressin (Acetate)

Details: Effects of Desmopressin enhanced by Indomethacin.
Ibuprofen

Interaction of Ibuprofen with Desmopressin (Acetate)

Loperamide (HCl)

Interaction of Loperamide (HCl) with Desmopressin (Acetate)

Details: Plasma concentration of oral Desmopressin increased by Loperamide.Loperamide increase fastrointestinal absorption of desmopressin.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

Desmopressin (Acetate)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

10 to 40 ug25 (25)As recommended.Intra NasalSingle dose or may be given in 2-3 divided doses.
300 to 400 ng/kg350 (350)As recommended.IV infusionGiven over 15 to 30 min for haemophillia or type I von Willebrand's disease and also given for testing of fibirinolytic response
200 to 400 ug300 (300)As recommended.OrallyFor primary nocturnal enuresis.
100 ug100 (100)8 hourlyOrallyAs in initial dose for cranial diabetes insipidus.
0.1 to 0.2 mg0.15 (0.15)8 hourlyPO

Paedriatic Dosage (20kg)

0.04 ug/kg0.04 (0.04)As recommended.Intra MuscularSingle dose recommended in diabetes incipidus
0.04 ug/kg0.04 (0.04)As recommended.Intra VenousSingle dose recommended in diabetes incipidus
2.5 to 20 ug11 (11.25)12 hourlyNasal
10 ug10 (10)8 hourlyOralFor 1 month to 2years. Given as initial dose and adjusted according to response.
50 ug50 (50)8 hourlyOrallyfor 2 to 12 year.
100 ug100 (100)8 hourlyOrallyfor 12 to 18 years

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Desmopressin (Acetate) is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Desmopressin (Acetate)

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Manufacturers of Desmopressin (Acetate) in Pakistan

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