Doxorubicin (HCl)

Overview

Doxorubicin (HCl)/Adriamycin HCl is antineoplastic agent, also called as anticancerous drug. Doxorubicin (HCl) is the prototype agent of anthracycline antibiotic, isolated from Streptomyces peucetius var caesius. It contains an amino sugar and an anthracycline ring. Doxorubicin (HCl) is among the most useful cytotoxic anticancerous drugs. It has a broad spectrum of potent activity against many different types of cancers specially haematologic malagnancies. Doxorubicin (HCl) is used in combination with different anticancerous drugs to obtain best therapeutic effects and to reduce the side effects or toxcities.

Categories

• 8 Antineoplastics, immunomodulators and drugs used in palliative care
  • 8.2 Cytotoxic (anti-neoplastic) drugs

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Doxorubicin (HCl) is contraindicated in conditions like Cardiac arrhythmia, Pregnancy, Breast feeding.

Drug Interactions

Side Effects

Dosage

Doxorubicin (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
60 to 75 mg/sq.meter	68 (67.5)	As recommended.	IV	Every 3rd Week, or As Required
Paedriatic Dosage (20kg)
60 to 90 mg/sq.meter	75 (75)	As recommended.	IV Infusion	Over 96 Hours, every 3-4 weeks
Neonatal Dosage (3kg)
No data regarding the neonatal dosage details of Doxorubicin (HCl) is available.

High Risk Groups

Warning / Precautions

Storage Conditions

Inj (reconstituted soln)

Store at room temperature, or in refrigerator. Protect from Sunlight. Use within 48 hrs if refrigerated and within 24 hrs if kept at room temperature.

Interference in Pathology

Brands / Trade Names of Doxorubicin (HCl)

Manufacturers of Doxorubicin (HCl) in Pakistan

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