Adrenaline

Overview

Adrenaline is a sympathomimetic amine, alpha-and beta-adrenoreceptor agonist, synthesized from tyrosine in the adrenal medulla and released along with small quantities of nor-it into blood stream, upon stimulation by the central nervous system in response to stress, anger or fear, acting to increase heart rate, blood pressure, cardiac output and carbohydrate metabolism. Adrenaline is a very potent vasoconstrictor and cardiac stimualnt. It also acts as a bronchodialator (dilates the bronchi i.e. air passage) and relieves respiratory discomfort in bronchial asthma and emphysema.

Categories

• 1 Drugs used in anesthesia
  • 1.2 Local anesthetics

• 3 Anti-allergics (Antihistamines) and drugs used in anaphylaxis

• 12 Cardiovascular drugs
  • 12.2 Antiarrhythmic drugs

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Adrenaline's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.5 to 2 %	1.2 (1.25)	As recommended.	Eye Drops	use in 5-10 mintues after administration of a mitotic eye drop For open angle Glaucoma
500 to 1000 mcg	750 (750)	As recommended.	IM	Adrenaline should be given every 5 minutes For Anaphylaxis, Bronchospam and allergy.
200 to 500 mcg	350 (350)	As recommended.	SC	Every 20-25 minutes
2 to 20 ug/min	11 (11)	As recommended.	Slow-IV	or 1 mg for 2-3 minutes upto 1 hour for Cardiac Arrest
2 to 20 ug/min	11 (11)	As recommended.	Solution	1:1,000 Solution. for bleeding forocal anesthesia : minimum : 1:80,000 , maximum 1:200000
2 to 3 mg	2.5 (2.5)	As recommended.	Via ETT	Every 15-30 Minutes, As Required
Paedriatic Dosage (20kg)
100 to 0 mcg/kg	50 (50)	As recommended.	ETT	dose may increase upto 100mcg/kg for advance cardiace life support
120 to 250 mcg/kg	180 (185)	As recommended.	Intra Muscular	Single Dose
10 to 0 mcg/kg	5 (5)	As recommended.	IV	dose may increase upto 100mcg/kg for advance cardiace life support
Neonatal Dosage (3kg)
0.006 to 0.012 mg/kg	0.009 (0.009)	As recommended.	Intramuscular	Single dose

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Adrenaline

Manufacturers of Adrenaline in Pakistan

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