Isotretinoin
Overview
Isotretinoin is the 13-cis-retinoic acid, a vitamin A derivative, used systematically for treatment of severecystic and conglobulate acne acne not responsive to antibiotic therapy. Thought to act directly on sebaceous glands in the skin to reduce sebum production and alters the lipid composition of the skin surface.
Categories
- 13 Dermatological drugs (topical)
- 13.5 Drugs affecting cell differentiation and proliferation
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Isotretinoin's dosage details are as follows:
Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
500 ug | 500 (500) | 24 hourly | PO | Initial oral dose for acne with food amdatjust up to 1 mg/kg according to response. |
0.05 % | 0.05 (0.05) | 12 hourly | Topical,gel | For 8 Weeks |
Paedriatic Dosage (20kg)
|
| | | | Doses not established for this age group |
Neonatal Dosage (3kg)
|
| | | | Not recommended in this age group |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Isotretinoin
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