Labetalol

Overview

Labetalol (HCl) is oral and parenteral competitive cocdirselective ß -adrenergic and selective postsynaptic a-1 adrenergic receptor blocker. Due to the presence of two optical centers, there are four diastereoisomers of labetolol, each of which displays different relative activities. The drug mixture possesses three to seven times greater ß -blocking activity than a-1 -blocking activity. Labetalol is clinically used in the treatment of hypertension associated with a variety of conditions. Labetalol was approved by the FDA for use in August 1984. Labetalol (HCl) is a reversible ß blocker with concurrent a1 blocking actions that produces peripheral vasodialation.lt blocks ß1-receptors in the heart, ß 2-receptors in bronchial and vascular smooth muscle, and a 1receptors in vascular smooth muscle. The ß-blocking activity is three to seven times as potent as the a-blocking ability.The result of labetalol's actions at a- and ß-receptors leads to vasodilation and decreased total peripheral resistance, which results in decreased blood pressure without a substantial decrease in resting heart rate, cardiac output, or stroke volume

Categories

• 12 Cardiovascular drugs
  • 12.3 Anti-hypertensives
  • 12.3.1 Beta blocking agents

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Labetalol's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
10 to 20 mg	15 (15)	As recommended.		With increasements of 5 to 10 mg if satisfactory hypotension is not acheived after 5 minutes.
15 to 20 mg/hr	18 (17.5)	As recommended.	Iv infusion	Initial rate & gradually increased to a dose of 120 mg/hr in hypertention after myocardial infection & 160 mg for hypertension hour in pregnancy.
100 to 200 mg	150 (150)	As recommended.	oral	Twice per day.
100 mg	100 (100)	12 hourly	oral	Initially with food.
2.85 to 34.28 mg/kg	19 (18.565)	As recommended.	PO	As Required
Paedriatic Dosage (20kg)
0.5 to 0 mg/kg/hour	0.25 (0.25)	As recommended.		To maximum of 3mg/kg/hour,For 1 month to 12 years.
30 to 0 mg/hour	15 (15)	As recommended.		12-18 years.
Neonatal Dosage (3kg)
No data regarding the neonatal dosage details of Labetalol is available.

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Labetalol

Manufacturers of Labetalol in Pakistan

Back to top