Vigabatrin

Overview

Vigabatrin is anticonvulsant agent. Vigabatrin is analogue of GABA (gamma amino-butyric acid). GABA is an inhibitory neurotransmitter, which is thought to be deficient in epilepsy, and able to stabilise discharges from epileptic foci. Vigabatrin is used in treatment of epilepsy, especially when not controlled by other drugs.

Primary Characterstics

Indications

Vigabatrin is primarily indicated in conditions like Epilepsy, Infantile spasms, and can also be given in adjunctive therapy as an alternative drug of choice in Iron deficiency anaemia.

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Pharmacokinetics

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Contraindications

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Drug Interactions

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Side Effects

The signs and symptoms that are produced after the acute overdosage of Vigabatrin include Coma, Vertigo, Unconsciousness, Tremor.

The symptomatic adverse reactions produced by Vigabatrin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Irritability, Ataxia, Nervousness, Confusion, Depression, Psychosis, Diplopia, SomnolenceX.

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Dosage

Vigabatrin's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

21.429 to 57.143 mg/kg39 (39.286)24 hourlyPO-

Paedriatic Dosage (20kg)

20 to 50 mg/kg35 (35)12 hourlyOral-

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Vigabatrin is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Vigabatrin

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Manufacturers of Vigabatrin in Pakistan

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