Zafirlukast

Overview

A leukotriene receptor inhibitor, effective in asthma. It is a selective antagonist of leukotriene D 4 recptor, stimulation of which by circulating leukotrienes is thought to play a role in pathogenesis of asthma. It suppresses both early and late bronchoconstrictor responses to inhaled antigens and irritants.

Categories

Primary Characterstics

Indications

Back to top

Pharmacokinetics

Back to top

Contraindications

Back to top

Drug Interactions

Zafirlukast is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Theophylline

Interaction of Theophylline with Zafirlukast

Erythromycin

Interaction of Erythromycin with Zafirlukast

Aspirin

Interaction of Aspirin with Zafirlukast

Details: Aspirin increases plasma concentration of leukotriene antagonists (e.g Zafirlukast).

Moderate (Sequence important)

Warfarin (Na)

Interaction of Warfarin (Na) with Zafirlukast

Details: Zafirlukast may decrease the metabolism, via CYP isoenzymes, of Warfarin.
Management: Monitor for increased prothrombin time (PT)/effects of Warfarin if zafirlukast is initiated/dose increased, or decreased PT/effects if zafirlukast is discontinued/dose decreased.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Back to top

Side Effects

Back to top

Dosage

Exemestane's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage
20 mg20 (20)12 hourlyPO

Paedriatic Dosage (20kg)
No data regarding the Paedriatic dosage details of Exemestane is available.

Neonatal Dosage (3kg)
No data regarding the neonatal dosage details of Exemestane is available.

High Risk Groups

Back to top

Warning / Precautions

Back to top

Storage Conditions

Tab

Store in a well closed container, Between 20°C-25°C. Do not Freeze. Protect from Sunlight and Moisture.

Back to top

Interference in Pathology

Back to top

Brands / Trade Names of Exemestane

Back to top

Manufacturers of Zafirlukast in Pakistan

Back to top

Previous Drug Generic - Next Drug Generic


Suggested Pages