Reserpine

Overview

Ethosuximide is antiepileptic agent. It was introduced in 1960 as the third of three marketed succinimides. its origin is in the cyclic ureide structure. It has a considerable efficasy against pentylenetetrazol seizures and was introduced as a 'pure petit mal' drug. its popularity continues, based on its safety and efficasy. its role as the first choice anti-absence drug remains undiminished, in part because of the idiosyncratic hepatotoxicity of the alternative drug, valproic acid. Ethosuximide is administered orally.

Categories

Primary Characterstics

Molecular Structure of Reserpine

It is of Synthetic origin. . The Molecular Weight of Reserpine is 608.70.

Its pKa is 6.6.

Indications

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Pharmacokinetics

Oral absorption of Ethosuximide is found to be 97% ±2. Volume of distribution is found to be 0.7 l/kg and plasma protien binding is negligible. Presystemic metabolism is noted to be 0.00255% ±0.00155 and metabolism is reported hepatic. Renal Excretion accounts for 17-38% and plasma half life is 53-56 hr.

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Contraindications

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Drug Interactions

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Side Effects

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Dosage

Reserpine's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

0.1 to 1 mg0.55 (0.55)24 hourlyPO

Paedriatic Dosage (20kg)

No data regarding the Paedriatic dosage details of Reserpine is available.

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Reserpine is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

Caps, Syrup

Store in a well closed container, Below 30°C.

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Interference in Pathology

  • Urinanalysis
  • Liver Function Test (LFT)

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Brands / Trade Names of Reserpine

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Manufacturers of Reserpine in Pakistan

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