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Overview

Categories

No Categories Defined

Primary Characterstics

Molecular Structure of Clonazepam

It is of Synthetic origin and belongs to Benzodiazepines. It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Benzodiazepine pharmacological group.The Molecular Weight of Clonazepam is 315.70.

Its pKa is 1.5, 10.5.

Indications

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Pharmacokinetics

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Contraindications

Clonazepam is contraindicated in conditions like Respiratory depression, Acute pulmonary insufficiency, Hypersensitivity.

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Drug Interactions

Clonazepam is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Phenytoin (Na)

Interaction of Phenytoin (Na) with Clonazepam

Alcohol

Interaction of Alcohol with Clonazepam

Phenobarbitone

Interaction of Phenobarbitone with Clonazepam

Phenytoin (Na)

Interaction of Phenytoin (Na) with Clonazepam

Lacosamide

Interaction of Lacosamide with Clonazepam

Carbamazepine

Interaction of Carbamazepine with Clonazepam

Details: Carbamazepine often reduces plasma concentration of Clonazepam.
Valproic Acid

Interaction of Valproic Acid with Clonazepam

Details: Concurrent administration has been associated with the development of absence status epileptitis,however this complication appears to be rare.
VORICONAZOLE

Interaction of VORICONAZOLE with Clonazepam

Details: Voriconazole may increase the serum concentration of clonazepam by decreasing its metabolism.
Management: Monitor for clonazepam toxicity if voriconazole is initiated or dose increased.

Moderate

Iproniazid Phosphate

Interaction of Iproniazid Phosphate with Clonazepam

Details: Infrequent reports of CLONAZEPAM increasing the EXTRAPYRAMIDAL side effects of IPRONIAZID.
Iprindole

Interaction of Iprindole with Clonazepam

Details: Theoretical potential for CLONAZEPAM increasing the SEDATIVE effect of IPRINDOLE.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage
No data regarding the Adult dosage details of is available.

Paedriatic Dosage (20kg)
No data regarding the Paedriatic dosage details of is available.

Neonatal Dosage (3kg)
No data regarding the neonatal dosage details of is available.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

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Warning / Precautions

It should be used with caution in patients with chronic pulmonary insufficiency, or impairment of hepatic or renal function and in debilitated patients. Perform periodic blood counts and liver function tests during long term therapy. Clonazepam should be used with caution in patients if increased salivation cause respiratory difficulty, because it may produce an increase in salivation. Give least amount of drug to patients in whom depression accompanies anxiety and suicidal tendencies may be present. It should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity because it may cause allergic reaction (including bronchial asthma).

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Storage Conditions

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Interference in Pathology

  • Liver Function Test (LFT)
  • Periodic blood count

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Brands / Trade Names of

Click on the desired strength of the dosage form to view its available brands.

Single Ingredient

Drops: 0.25 %w/v,
Tabs: 1 mg, 2 mg, 0.5 mg,

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Manufacturers of in Pakistan

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