Chlorpromazine (HCl)

Overview

Chlorpromazine (HCl) is the hydrochloride salt of chlorpromazine which is a phenothiazine derivative. It is used as an antiemetic, antipsychotic and tranquilizer. Chlorpromazine (HCl) is administered by rectal suppositories.

Categories

• 24 Psychotherapeutic drugs
  • 24.1 Drugs used in psychotic disorders

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Chlorpromazine (HCl) is contraindicated in conditions like Epilepsy, Myasthenia gravis, Narrow-angle glaucoma, Parkinson's disease, Depressed level of conciousness.

Drug Interactions

Side Effects

Dosage

Chlorpromazine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
25 to 50 mg	38 (37.5)	As recommended.	IV,IM	Repeated every 4-6hours. To maximum of 400 mg.
10 to 25 mg	18 (17.5)	8 hourly	PO
Paedriatic Dosage (20kg)
0.5 mg/kg	0.5 (0.5)	6 hourly	Intra Muscular	Should not be used under 6 months of age.
0.5 mg/kg	0.5 (0.5)	6 hourly	Intra Venous	Should not be used under 6 months of age.
0.5 mg/kg	0.5 (0.5)	6 hourly	Oral	Should not be used under 6 months of age.
Neonatal Dosage (3kg)
0.5 mg/kg	0.5 (0.5)	4 hourly	Intramuscular
0.5 mg/kg	0.5 (0.5)	4 hourly	Intravenous
0.5 mg/kg	0.5 (0.5)	4 hourly	oral

High Risk Groups

Warning / Precautions

Chlorpromazine should be used with caution in patients exposed to extreme heat or phosphorus insecticides, patients in state of alcohol withdrawal, patients with history of peptic ulcer, allergic reactions, with renal impairment, prostatic hypertrophy. Photosensitization may occur, caution patients to take appropriate measures (e.g.wear protective clothing or sunscreen) against exposure to sunlight or ultra violet light. Discontinue use atleast 48 hours before myelography.

Storage Conditions

Interference in Pathology

Brands / Trade Names of Chlorpromazine (HCl)

Manufacturers of Chlorpromazine (HCl) in Pakistan

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