Chlorpromazine (HCl)

Overview

Chlorpromazine (HCl) is the hydrochloride salt of chlorpromazine which is a phenothiazine derivative. It is used as an antiemetic, antipsychotic and tranquilizer. Chlorpromazine (HCl) is administered by rectal suppositories.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

Chlorpromazine (HCl) is contraindicated in conditions like Epilepsy, Myasthenia gravis, Narrow-angle glaucoma, Parkinson's disease, Depressed level of conciousness.

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Drug Interactions

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Side Effects

The severe or irreversible adverse effects of Chlorpromazine (HCl), which give rise to further complications include Cholestatic jaundice, Cholestatic jaundice, Photosensitivity, Paralytic ileus, Impotence, Blood dyscrasias, Gynecomastia, Respiratory failure, bilirubinemia, icterus, blood dyscrasias.

Chlorpromazine (HCl) produces potentially life-threatening effects which include Seizures, Blood dyscrasias, Neuroleptic Malignant Syndrome, Temperature disorders, Ventricular arrhythmias, Neuroleptic malignant syndrome, Jaundice, Tradive dyskinesia. which are responsible for the discontinuation of Chlorpromazine (HCl) therapy.

The signs and symptoms that are produced after the acute overdosage of Chlorpromazine (HCl) include Hypotension, Tachycardia, Coma, Hypothermia, Tachypnea, Decreased diastolic BP, Somnolence.

The symptomatic adverse reactions produced by Chlorpromazine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Constipation, Insomnia, Skin rashes, Dry mouth, Blurred vision, Allergic reactions, Akathisia, Nasal stiffiness, Weight gain, Diaphoresis, Acute dystonia, Skin pigmentation, Faintness, Decrease in libido, Galactorrhea, HyperprolactinemiaX, Adverse behavioral reactions, Amenorrhea, Xerostomia, Ocular complicaions, Urinary retention, Dry mouth, Skin rashes, dizziness, faintness, Palpitations, anticholnergic efforts, worsening of glaucoma.

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Dosage

Chlorpromazine (HCl)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

25 to 50 mg38 (37.5)As recommended.IV,IMRepeated every 4-6hours. To maximum of 400 mg.
10 to 25 mg18 (17.5)8 hourlyPO

Paedriatic Dosage (20kg)

0.5 mg/kg0.5 (0.5)6 hourlyIntra MuscularShould not be used under 6 months of age.
0.5 mg/kg0.5 (0.5)6 hourlyIntra VenousShould not be used under 6 months of age.
0.5 mg/kg0.5 (0.5)6 hourlyOralShould not be used under 6 months of age.

Neonatal Dosage (3kg)

0.5 mg/kg0.5 (0.5)4 hourlyIntramuscular
0.5 mg/kg0.5 (0.5)4 hourlyIntravenous
0.5 mg/kg0.5 (0.5)4 hourlyoral

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Chlorpromazine (HCl)

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Manufacturers of Chlorpromazine (HCl) in Pakistan

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