Moexipril

Overview

Moexipril is an oral angiotensin-converting enzyme (ACE) inhibitor and is used to treat hypertension. Like quinapril and ramipril, the active metabolite is produced by deesterification from the prodrug. Moexiprilat (the deesterified form), is about 1000 times active than moexipril itself and antihypertensive activity entirely depends on this metabolite. Prolonged antihypertensive effects allow for once-daily dosing. The dosage range is halved in patients who are taking diuretics or who have renal impairment. It was approved by FDA on April 19, 1995.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

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Side Effects

The severe or irreversible adverse effects of Moexipril, which give rise to further complications include Fever, Allergic reactions, Chest pain, Irregular heart beat.

The signs and symptoms that are produced after the acute overdosage of Moexipril include fatigue, Dizziness, Fainting, Weakness.

The symptomatic adverse reactions produced by Moexipril are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Diarrhea, Anxiety, Palpitation, Rashes, Itching, Flushing, Chest pain.

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Dosage

Moexipril's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

3.75 mg3.8 (3.75)24 hourlyPOInitial dose: Should be taken 1 hour prior to meals.
7.5 to 30 mg/day19 (18.75)24 hourlyPOMaintenance dose: Should be taken in 1-2 divided doses 1 hour before meals.

Paedriatic Dosage (20kg)

No data regarding the Paedriatic dosage details of Moexipril is available.

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Moexipril is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Moexipril

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Manufacturers of Moexipril in Pakistan

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