Botulinum B Toxin
Overview
Botulinum B Toxin is an exotoxin produced by germinating spores and growing cells of Clostridium botulinum. It binds to presynaptic terminals of the central nervous system and inhibits the calcium-ion mediated release of acetylcholine at the motor nerve terminals, leading to flaccid paralysis of the affected muscles. Paralysis persists for about 2-3 months (until new nerve terminals form). The actions and uses are similar to those of Botulinum type A toxin, but due to antigenically distinct they have the potential for use in patients who develop resistance to botulinum toxin treatment due to the development of antibodies of type A toxin.
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Botulinum B Toxin's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 5000 to 1000 units | 3000 (3000) | As recommended. | IM | administer in 2 to 4 divided doses. |
Paedriatic Dosage (20kg)
|
| No data regarding the Paedriatic dosage details of Botulinum B Toxin is available. |
Neonatal Dosage (3kg)
|
| No data regarding the neonatal dosage details of Botulinum B Toxin is available. |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Botulinum B Toxin
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Manufacturers of
Botulinum B Toxin
in Pakistan
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