Danazol

Overview

Danazol is an isoxazole derivative of ethisterone (17a-ethinyl testosterone). It has weak progestational and androgenic activities. It is a synthetic androgen (hormone). itused to treat pain and infertility caused by endometriosis (a condition involving the tissue of the uterus). italso used in the treatment of cysts or lumps in the breast.

Categories

  • 18 Hormones and other endocrine drugs and contraceptives

Primary Characterstics

Indications

Danazol is primarily indicated in conditions like Benign breast disease, Endometriosis, Gynaecomastia, Long term management of hereditary angioedema, Menorrhagia, Premenstrual syndrome, Severe pain and tenderness in benign fibrocystic breast disease, Treatment of endometriosis, and can also be given in adjunctive therapy as an alternative drug of choice in Angioedema, Idiopathic thrombocytopenic purpura.

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Pharmacokinetics

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Contraindications

Danazol is contraindicated in conditions like Vaginal bleeding, Porphyria, Thrombo-embolic complications.

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Drug Interactions

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Side Effects

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Dosage

Danazol's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

200 to 800 mg500 (500)As recommended.POgiven in 2 divided doses daily for 3-6months. upto 9 months if necessary.

Paedriatic Dosage (20kg)

10 to 40 25 (25)24 hourlyOral

Neonatal Dosage (3kg)

Not recommended in this age group

High Risk Groups

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Warning / Precautions

Danazol should not be used during pregnancy or lactation. It should be usedwith caution in-patients with migraine headaches, heart, liver or kidney disease, a history of seizures, breast cancer, abnormal bleeding, previous strokes, prostate cancer or any other diseases. Extreme caution is advised for use in children. Pediatric specialist consultation is also advised. Geriatric men are at increased risk of developing enlarged prostate and prostate cancer with the use of androgen-like drugs, so use cautiously.

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Storage Conditions

Caps

Store Below 40°C. Protect from Sunlight and Moisture.

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Interference in Pathology

  • Interferes with Thyroid Function Test

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Brands / Trade Names of Danazol

Click on the desired strength of the dosage form to view its available brands.

Single Ingredient

Tabs: 200 mg,
Caps: 100 mg, 200 mg,

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Manufacturers of Danazol in Pakistan

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