Infliximab

Overview

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

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Side Effects

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Dosage

Infliximab's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

5 mg/kg5 (5)24 hourlyIV Inductionat 0, 2 and 6 weeks followed by a maintenance regimen of 5 mg/kg every 8 weeks (For Crohn's disease). For adult patients who respond and then lose their response, consideration may be given to treatment with 10 mg/kg. Patients who do not respond by Week 14 are unlikely to respond with continued dosing and consideration should be given to discontinue Infliximab in these patients.
5 mg/kg5 (5)24 hourlyIV Inductionat 0, 2 and 6 weeks followed by a maintenance regimen of 5 mg/kg every 8 weeks thereafter for the treatment of moderately to severely active ulcerative colitis.
3 mg/kg3 (3)24 hourlyIV Inffollowed with additional similar doses at 2 and 6 weeks after the first infusion then every 8 weeks thereafter. (for Rheumatoid Arthritis). For patients who have an incomplete response, consideration may be given to adjusting the dose up to 10 mg/kg or treating as often as every 4 weeks bearing in mind that risk of serious infections is increased at higher doses.
5 mg/kg5 (5)24 hourlyIV Inffollowed with additional similar doses at 2 and 6 weeks after the first infusion, then every 6 weeks thereafter. (for Ankylosing Spondylitis)
5 mg/kg5 (5)24 hourlyIV Inffollowed with additional similar doses at 2 and 6 weeks after the first infusion then every 8 weeks thereafter. (for Psoriatic Arthritis)
5 mg/kg5 (5)24 hourlyIV Inffollowed with additional similar doses at 2 and 6 weeks after the first infusion then every 8 weeks thereafter. (for Plaque Psoriasis)

Paedriatic Dosage (20kg)

5 mg/kg5 (5)As recommended.IV infusionFollowed by additional 5mg/kg infusion doses at 2 & 6 weeks.

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Infliximab is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Infliximab

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Manufacturers of Infliximab in Pakistan

Bayer

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