Olopatadine

Overview

Olopatadine is a potent selective antiallergic/antihistaminic agent. It has multiple distinct mechanisms of action. It antagonises histamine (the primary mediator of allergic response in humans) and prevents histamine induced inflammatory cytokine production by human conjunctival epithelial cells. Data from in vitro studies suggest that it may act on human conjunctival mast cells to inhibit the release of pro-inflammatory mediators. In patients with patent nasolacrimal ducts, topical ocular administration of olopatadine was suggested to reduce the nasal signs and symptoms that frequently accompany seasonal allergic conjunctivitis. It does not produce a clinically significant change in pupil diameter.

Categories

• 21 Ophthalmological preparations
  • 21.6 Non-specific anticonjunctivitis preparations

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Olopatadine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2.22 to 0 mg/ml	1.1 (1.11)	24 hourly	opthalmic	The dose is one drop of olopatadine in the conjunctival sac of the affected eye(s) twice daily (8 hourly). Treatment may be maintained for up to four months, if considered necessary.
Paedriatic Dosage (20kg)
2.22 to 0 mg/ml	1.1 (1.11)	24 hourly	opthalmic	The dose is one drop of olopatadine in the conjunctival sac of the affected eye(s) twice daily (8 ho
Neonatal Dosage (3kg)
2.22 to 0 mg/ml	1.1 (1.11)	24 hourly	opthalmic	The dose is one drop of olopatadine in the conjunctival sac of the affected eye(s) twice daily (8 hourly). Treatment may be maintained for up to four months, if considered necessary.

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Olopatadine

Manufacturers of Olopatadine in Pakistan

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