Ceftaroline fosamil
Overview
Ceftaroline fosamil is broad-spectrum, prodrug antibacterial of cephalosporin class of beta-lactams (ß-lactams).
Chemically, the prodrug, ceftaroline fosamil monoacetate monohydrate is (6R,7R)-7-{(2Z)-2-(ethoxyimino)-2-[5- (phosphonoamino)-1,2,4 thiadiazol-3-yl]acetamido}-3-{[4-(1-
methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl}8-oxo-5-
thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate monoacetate
monohydrate. The empirical formula is C22H21N8O8PS4•C2H4O2•H2O.
Categories
- 6 Anti-infective drugs
- 6.2 Antibiotics, systemic
Primary Characterstics
Indications
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Pharmacokinetics
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Side Effects
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Dosage
Ceftaroline fosamil's dosage details are as follows:
Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
200 to 200 mg | 200 (200) | 12 hourly | IV infusion | (For patient with end-stage renal disease (ESRD), including hemodialysis) IV infusion administered over 1 hour. Constitution time is less than 2 minutes. Mix gently and check that the content has dissolved. |
300 to 300 mg | 300 (300) | 12 hourly | IV infusion | (For patient with creatinine clearance 15-30 ml/min) IV infusion administered over 1 hour |
400 to 400 mg | 400 (400) | 12 hourly | IV infusion | (For patient with
creatinine clearance 30-50 mL/min ) IV infusion administered over 1 hour |
600 to 600 mg | 600 (600) | 12 hourly | IV infusion | (For patient with normal renal function) IV infusion administered over 1 hour in adults = 18 years of age |
Paedriatic Dosage (20kg)
|
No data regarding the Paedriatic dosage details of Ceftaroline fosamil is available. |
Neonatal Dosage (3kg)
|
No data regarding the neonatal dosage details of Ceftaroline fosamil is available. |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
No data regarding the pathological interferences produced by Ceftaroline fosamil is available.
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Brands / Trade Names of
Ceftaroline fosamil
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Manufacturers of
Ceftaroline fosamil
in Pakistan
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