Sorafenib

Overview

Sorafenib as sorafenib tosylate is an antineoplastic agent and shows its activity by kinase inhibitor.Sorafenib tosylate has the chemical name 4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)N2methylpyridine-2-carboxamide 4-methylbenzenesulfonate

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

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Side Effects

The severe or irreversible adverse effects of Sorafenib, which give rise to further complications include Hypertension, Hemorrhage, Myocardial infarction, gastrointestinal perforation, drug induced hepatitis.

The symptomatic adverse reactions produced by Sorafenib are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fatigue, Nausea, Alopecia, Anorexia, Diarrhea, Abdominal pain, Weight loss, Alopecia, Rash.

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Dosage

Sorafenib's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

400 to 800 mg600 (600)As recommended.POat least 1 hour before or 2 hours after a meal

Paedriatic Dosage (20kg)

No data regarding the Paedriatic dosage details of Sorafenib is available.

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Sorafenib is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Sorafenib

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Manufacturers of Sorafenib in Pakistan

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