Severity N/A
IVABRADINE Interaction of IVABRADINE with Dabrafenib
Carbamazepine Interaction of Carbamazepine with Dabrafenib
Details: Strong CYP3A4 inducers may decrease levels of dabrafenib.
Management: Consider alternate therapy.
Clarithromycin Interaction of Clarithromycin with Dabrafenib
Details: Strong CYP3A4 inhibitors may increase levels of dabrafenib
Management: Consider alternate therapy.
Gemfibrozil Interaction of Gemfibrozil with Dabrafenib
Details: Strong CYP3A4 inhibitors may increase levels of dabrafenib.
Management: consider alternate therapy
Ketoconazole Interaction of Ketoconazole with Dabrafenib
Details: Strong CYP3A4 inhibitors may increase levels of dabrafenib
Management: Consider alternate therapy
Midazolam Interaction of Midazolam with Dabrafenib
Details: Dabrafenib decreased systemic exposure of midazolam (a substrate of CYP3A4)
Management: Substitute for these medications or monitor patients for loss of efficacy.
Nefazodone (HCl) Interaction of Nefazodone (HCl) with Dabrafenib
Details: Strong CYP3A4 inhibitors may increase levels of dabrafenib
Management: consider alternate therapy
Pantoprazole Interaction of Pantoprazole with Dabrafenib
Details: Proton pump inhibitors may alter the solubility of dabrafenib and reduce its bioavailability
Phenobarbital Sodium Interaction of Phenobarbital Sodium with Dabrafenib
Details: Strong CYP3A4 inducers may decrease levels of dabrafenib
Management: Consider alternate therapy
Phenytoin (Na) Interaction of Phenytoin (Na) with Dabrafenib
Details: Strong CYP3A4 inducers may decrease levels of dabrafenib
Management: Consider alternate therapy
Ranitidine Interaction of Ranitidine with Dabrafenib
Details: H2-receptor antagonists may alter the solubility of dabrafenib and reduce its bioavailability
Rifampicin Interaction of Rifampicin with Dabrafenib
Details: Strong CYP3A4 inducers may decrease levels of dabrafenib
Management: consider alternate therapy