Acetylcysteine

Overview

Acetylcysteine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
3 to 5 ml	4 (4)	4 hourly	Inhalation	As 20% solution for mucolytic effect inhaled as nebulizer 3-4 times/day.
6 to 10 ml	8 (8)	6 hourly	Nebulizer	3-5ml of 20% solution as nebulizer for mucolytic effect. 2 Nebulizations in each nostril.
			Opthalmic	For dry eye associated with abnormal mucus production, acetylcysteine, usually as a 5% solution with hypromellose, is given topically 3 or 4 times daily.
140 to 140 mg/Kg	140 (140)	As recommended.	PO	This is an initial dose for Paracetamol poisning. Give 140mg/Kg as 5% solution.
70 to 70 mg/Kg	70 (70)	4 hourly	PO	For Paracetamol poisning: Give 17 doses of 70mg/Kg after initial dose with an interval of 4 hours.
600 to 600 mg	600 (600)	As recommended.	PO	As mucolytic in usual dose of 600 mg daily as a single dose or in three divided doses.
Paedriatic Dosage (20kg)
0.125 mg/kg.min	0.12 (0.125)	As recommended.	IV Infusion	Maintenance for 20 Hours, As Required
10 mg/kg.min	10 (10)	As recommended.	IV Infusion	Initially for 15 Minutes
2 to 3 gm	2.5 (2.5)	12 hourly	PO
Neonatal Dosage (3kg)
0.125 mg/kg/min	0.12 (0.125)	As recommended.	Infusion	Maintenance, over 20 hrs., As required
10 mg/kg/min	10 (10)	As recommended.	Infusion	Initial , For 15 minutes