Felodipine
Overview
Felodipine is a calcium channel blocker. It lowers the blood pressure by blocking calcium, relaxes the heart muscle and dilates the heart blood vessels. It has been known since the late 1800s that calcium influx was necessary for the contraction of muscle. The discovery of calcium channel in a cardiac muscle was followed by the finding of several diffent type of calcium channel in diffrent tissues. These discoveries provided the necessary mechanisms for the triggering of cardiac and smooth muscle contraction. The discovery of these channels also made possible the developemnet of clinically useful blocking drugs.
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Felodipine's dosage details are as follows:
Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
2.5 to 20 mg | 11 (11.25) | 24 hourly | PO | Maintenance |
5 mg | 5 (5) | 24 hourly | PO | Initial |
Paedriatic Dosage (20kg)
|
| | | | Not Recommended in this Age Group |
Neonatal Dosage (3kg)
|
| | | | Not recommended in this age group |
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
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Warning / Precautions
Felodipine should be used with caution in patients with pre-existing heart disease or liver disease.This drug should be used only if clearly needed during pregnancy or lactation. Limit alcohol while taking this medication because it can enhance dizziness. Avoid drinking grapefruit juice at the same time when take this medication.This medication may cause enlargement of the gums, this can be minimized by maintaining good oral hygiene with regular brushing, flossing and massaging of the gums.
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Storage Conditions
Tab
Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
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Interference in Pathology
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Brands / Trade Names of
Felodipine
Click on the desired strength of the dosage form to view its available brands.
Single Ingredient
Tabs: 5 mg, 10 mg,
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