Folinic Acid

Overview

Folinic Acid is the 5-formyl derivative of tetrahydrofolic acid. It can act as a co-enzyme carrier in certain folate mediated reactions. Folinic Acid is used as an antidote of antifolate cytotoxic agents and to treat megaloblastic anemia.

Categories

Primary Characterstics

It is of Synthetic origin and belongs to water soluble vitamin. It belongs to Hematological Agents and Antidotes pharmacological group.The Molecular Weight of Folinic Acid is 473.40.

Its pKa is 3.1, 4.8, 10.4.

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

Folinic Acid is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Fluorouracil

Interaction of Fluorouracil with Folinic Acid

Methotrexate

Interaction of Methotrexate with Folinic Acid

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

Folinic Acid's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

120 mg120 (120)As recommended.IV,IMIn div.doses over 12-24 hrs.

Paedriatic Dosage (20kg)

No data regarding the Paedriatic dosage details of Folinic Acid is available.

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Folinic Acid is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Folinic Acid

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Manufacturers of Folinic Acid in Pakistan

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