Alfacalcidol
Overview
Alfacalcidiol is an analog of vitamin D3, a fat soluble sterol, sometimes considered to be hormone or hormone precursor. Alfacalcidol is involved in promoting normal bone development in body by regulating calcium, phosphorus and minerals. Vitamin D is a secosteroid and sometimes popularly known as the 'sunshine vitamine' because formed in the skin from 7-dehydrocholesterol under the influence of ultraviolet irradiation. Alfacalcidol is also found in certain foods. Fish liver oils, especially code liver oil are good sources of vitamin D. Dairy products contain some vitamin but the potency varies with season. Alfacalcidiol was introduced into clinical use in the early 1970s. Alfacalcidol is prepared by total or partial chemical synthsis. Alfacalcidol is not available in any combination preparation.
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Alfacalcidol's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 0.25 to 1 mcg/kg | 0.62 (0.625) | 24 hourly | PO | Maintenance |
| 1 mcg | 1 (1) | 24 hourly | PO | Initial Dose, increased gradually |
Paedriatic Dosage (20kg)
|
| 0.05 ug/kg | 0.05 (0.05) | 24 hourly | Oral | - |
Neonatal Dosage (3kg)
|
| 0.05 mg/kg | 0.05 (0.05) | 24 hourly | oral | |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Alfacalcidol
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