Alteplase Overview Categories 10 Drugs affecting the blood10.2 Anticoagulants/Platelet deaggregators 12 Cardiovascular drugs12.5 Anti-thrombotic drugs and myocardial infarction Page headings Overview Primary Characterstics Indications Pharmacokinetics Contraindications Drug Interactions Side Effects Dosage High Risk Groups Warning / Precautions Storage Conditions Interference in Pathology Brands of Alteplase Manufacturers of Alteplase Primary Characterstics Indications Back to top Pharmacokinetics Back to top Contraindications Back to top Drug Interactions Back to top Side Effects Back to top Dosage Alteplase's dosage details are as follows: Dose Single Dose Frequency Route Instructions Adult Dosage 10 to 10 mg10 (10)As recommended.IVThis is the dose for pulmonary embolism. Give this initial IV dose over 1-2 minutes. This dose should be followed by 90mg by intravenous infusion over 2 hours, maximum 1.5 mg/Kg in patients less than 65 Kg.15 to 15 mg15 (15)As recommended.IVThis is the accelerated regimen for myocardial infarction. Initiate within 6 hours of symptom onset. This dose should be followed by 50mg by intravenous infusion over 30 minutes, then 35 mg over 60 minutes (total 100 mg over 90 minutes).15 to 15 mg15 (15)As recommended.IVThis is the accelerated regimen for myocardial infarction for patients less then 65 Kg weight. This dose should be followed by 0.75mg/Kg by intravenous infusion over 30 minutes, then 0.5mg/Kg over 60 minutes (total 100 mg over 90 minutes).10 to 10 mg10 (10)As recommended.IVThis is for myocardial infarction within 6-12 hours of symptom onset. This dose should be followed by 50mg by intravenous infusion over 60 minutes, then 4 infusions each of 10mg over 30 minutes (total 100 mg over 3 hours; maximum 1.5 mg/Kg in patients less than 65 Kg).900 to 900 mcg/Kg900 (900)As recommended.IVThis is the dose for acute stroke initiate within 4.5 hours of symptom onset. Infuse over 60 minutes (Maximum 90 mg); initial 10% dose by intraveous injection, remainder by IV infusion. Paedriatic Dosage (20kg) 0.75 mg/kg0.75 (0.75)As recommended.Intra VenousAs Required100 to 500 mcg/kg.hour300 (300)As recommended.IV-InfFor 3-6 hours; maximum 100 mg total daily dose; use ultrasound assessment to monitor effect before c Neonatal Dosage (3kg) 100 to 500 mg/kg/hour300 (300)As recommended.IV-InfIt can be given for 3-6 hours and ultrasound assessment to moniter effect before considering a second cause of treatment. High Risk Groups Back to top Warning / Precautions Back to top Storage Conditions Back to top Interference in Pathology Back to top Brands / Trade Names of Alteplase Back to top Manufacturers of Alteplase in Pakistan Back to top Previous Drug Generic - Next Drug Generic