Alteplase

Overview

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

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Side Effects

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Dosage

Alteplase's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

10 to 10 mg10 (10)As recommended.IVThis is the dose for pulmonary embolism. Give this initial IV dose over 1-2 minutes. This dose should be followed by 90mg by intravenous infusion over 2 hours, maximum 1.5 mg/Kg in patients less than 65 Kg.
15 to 15 mg15 (15)As recommended.IVThis is the accelerated regimen for myocardial infarction. Initiate within 6 hours of symptom onset. This dose should be followed by 50mg by intravenous infusion over 30 minutes, then 35 mg over 60 minutes (total 100 mg over 90 minutes).
15 to 15 mg15 (15)As recommended.IVThis is the accelerated regimen for myocardial infarction for patients less then 65 Kg weight. This dose should be followed by 0.75mg/Kg by intravenous infusion over 30 minutes, then 0.5mg/Kg over 60 minutes (total 100 mg over 90 minutes).
10 to 10 mg10 (10)As recommended.IVThis is for myocardial infarction within 6-12 hours of symptom onset. This dose should be followed by 50mg by intravenous infusion over 60 minutes, then 4 infusions each of 10mg over 30 minutes (total 100 mg over 3 hours; maximum 1.5 mg/Kg in patients less than 65 Kg).
900 to 900 mcg/Kg900 (900)As recommended.IVThis is the dose for acute stroke initiate within 4.5 hours of symptom onset. Infuse over 60 minutes (Maximum 90 mg); initial 10% dose by intraveous injection, remainder by IV infusion.

Paedriatic Dosage (20kg)

0.75 mg/kg0.75 (0.75)As recommended.Intra VenousAs Required
100 to 500 mcg/kg.hour300 (300)As recommended.IV-InfFor 3-6 hours; maximum 100 mg total daily dose; use ultrasound assessment to monitor effect before c

Neonatal Dosage (3kg)

100 to 500 mg/kg/hour300 (300)As recommended.IV-InfIt can be given for 3-6 hours and ultrasound assessment to moniter effect before considering a second cause of treatment.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Alteplase

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Manufacturers of Alteplase in Pakistan

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