Kanamycin (Acid Sulphate)
Overview
Bactericidal aminoglycoside antibiotic (the aminoglycosides are the compound containing characteristic amino sugars joined to a hexose nucleus in glycoside linkage, they are polycations and their polarity accounts for their pharmakokinetic peoperties). Kanamycin (Acid Sulphate) is derived from Streptomyces kanamyceticus, consisting of three components designated A, B and C. The clinically active form is a mixture of kanamycins A and B. Kanamycin has actions and spectrum similar to Neomycin, but less ototoxic. Used in gram -ve speticaemia, with monitoring of blood levels, perticularly in renal failure. Kanamycin (Acid Sulphate) is most often applied topically.
Categories
- 6 Anti-infective drugs
- 6.2 Antibiotics, systemic
- 6.2.2 Other anti-bacterial drugs
- 6 Anti-infective drugs
- 6.2 Antibiotics, systemic
Primary Characterstics
Indications
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Pharmacokinetics
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Side Effects
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Dosage
Kanamycin (Acid Sulphate)'s dosage details are as follows:
Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
500 mg | 500 (500) | 8 hourly | IV,IM | |
1 g | 1 (1) | 6 hourly | PO | For preoperative intestinal antisepsis. Frequency may be increased upto 6 times/day. Duration: For 3-4 days. |
8 to 12 g/day | 10 (10) | As recommended. | PO | For Hepatic encephalopathy. Shuold be given in divided doses. |
Paedriatic Dosage (20kg)
|
5 to 10 mg/kg | 7.5 (7.5) | 8 hourly | Intra Muscular | - |
5 to 10 mg/kg | 7.5 (7.5) | 8 hourly | Intra Venous | - |
Neonatal Dosage (3kg)
|
5 to 10 mg/kg | 7.5 (7.5) | 8 hourly | Intra Muscular | - |
5 to 10 mg/kg | 7.5 (7.5) | 8 hourly | Intra Venous | - |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Kanamycin (Acid Sulphate)
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Manufacturers of
Kanamycin (Acid Sulphate)
in Pakistan
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