Kanamycin (Acid Sulphate)

Overview

Bactericidal aminoglycoside antibiotic (the aminoglycosides are the compound containing characteristic amino sugars joined to a hexose nucleus in glycoside linkage, they are polycations and their polarity accounts for their pharmakokinetic peoperties). Kanamycin (Acid Sulphate) is derived from Streptomyces kanamyceticus, consisting of three components designated A, B and C. The clinically active form is a mixture of kanamycins A and B. Kanamycin has actions and spectrum similar to Neomycin, but less ototoxic. Used in gram -ve speticaemia, with monitoring of blood levels, perticularly in renal failure. Kanamycin (Acid Sulphate) is most often applied topically.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

Kanamycin (Acid Sulphate) is contraindicated in conditions like Neuromuscular blockade.

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Drug Interactions

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Side Effects

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Dosage

Kanamycin (Acid Sulphate)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

500 mg500 (500)8 hourlyIV,IM
1 g1 (1)6 hourlyPOFor preoperative intestinal antisepsis. Frequency may be increased upto 6 times/day. Duration: For 3-4 days.
8 to 12 g/day10 (10)As recommended.POFor Hepatic encephalopathy. Shuold be given in divided doses.

Paedriatic Dosage (20kg)

5 to 10 mg/kg7.5 (7.5)8 hourlyIntra Muscular-
5 to 10 mg/kg7.5 (7.5)8 hourlyIntra Venous-

Neonatal Dosage (3kg)

5 to 10 mg/kg7.5 (7.5)8 hourlyIntra Muscular-
5 to 10 mg/kg7.5 (7.5)8 hourlyIntra Venous-

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Kanamycin (Acid Sulphate)

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Manufacturers of Kanamycin (Acid Sulphate) in Pakistan

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