Mesalazine

Overview

Bactericidal aminoglycoside antibiotic (the aminoglycosides are the compound containing characteristic amino sugars joined to a hexose nucleus in glycoside linkage, they are polycations and their polarity accounts for their pharmakokinetic peoperties). Kanamycin (Acid Sulphate) is derived from Streptomyces kanamyceticus, consisting of three components designated A, B and C. The clinically active form is a mixture of kanamycins A and B. Kanamycin has actions and spectrum similar to Neomycin, but less ototoxic. Used in gram -ve speticaemia, with monitoring of blood levels, perticularly in renal failure. Kanamycin (Acid Sulphate) is most often applied topically.

Categories

Primary Characterstics

Indications

Mesalazine is primarily indicated in conditions like Crohn's disease, Ulcerative colitis.

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Pharmacokinetics

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Contraindications

Kanamycin (Acid Sulphate) is contraindicated in conditions like Neuromuscular blockade.

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Drug Interactions

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Side Effects

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Dosage

Kanamycin (Acid Sulphate)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

800 mg800 (800)8 hourlyPO
1 g1 (1)As recommended.Rectal(enema)
0.5 to 1.5 g1 (1)As recommended.Rectal(Supostories)

Paedriatic Dosage (20kg)

10 mg/kg10 (10)8 hourlyMaintanance ,To maximum of 500mg
15 to 0 mg/kg7.5 (7.5)8 hourlyFor acute attacks (maximum 1g)

Neonatal Dosage (3kg)

Not recommended in this age group

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Kanamycin (Acid Sulphate)

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Manufacturers of Mesalazine in Pakistan

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