Oxytetracycline (Dihydrate)
Overview
Oxytetracycline (Dihydrate) is a naturally occuring tetracycline, produced by Streptomyces rimosis. Like other tetracycline it has a broad spectrum of activity.it was introduced in 1950. Effective against a wide range of both gram positive and gram negative organisms.The main mechanism of action is on protien synthesis. In addtion to its antibiotic activity Oxytetracycline (Dihydrate) is also a chelating agent and will chelate Ca, Mg or Al ions in the gut. Oxytetracycline (Dihydrate) is administered orally and intramuculalrly. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Oxytetracycline (Dihydrate) is important to take the drug for the full time period as prescribed. Discontinuation of the drug may result in ineffective treatment.
Categories
- 6 Anti-infective drugs
- 6.2 Antibiotics, systemic
- 6.2.2 Other anti-bacterial drugs
Primary Characterstics
Indications
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Pharmacokinetics
Oral absorption of Oxytetracycline (Dihydrate) is found to be 60% . Volume of distribution is found to be 406.6 l/kg and plasma protien binding is 31%. Presystemic metabolism is noted to be 0.5% ±0.5 and metabolism is reported Hepatic. Renal Excretion accounts for 22.5% and plasma half life is 9.2 hr.
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Side Effects
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Dosage
Oxytetracycline (Dihydrate)'s dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 250 to 500 mg | 380 (375) | 6 hourly | PO | |
Paedriatic Dosage (20kg)
|
| | | | Not Recommended in Children under 12 Years |
Neonatal Dosage (3kg)
|
| | | | Not recommended in this age group |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Oxytetracycline (Dihydrate)
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Manufacturers of
Oxytetracycline (Dihydrate)
in Pakistan
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