Pralidoxime

Overview

Pralidoxime is a cholinesterase reactivator. Chemically Pralidoxime is 2-formyl-1-methylpyridinium. Pralidoxime is used as an antidote to reverse muscle paralysis resulting from organophosphate anticholinesterase pesticide poisoning. Because it does not significantly relieve depression of the respiratory center or decrease the muscarinic effects of anticholinesterase poisoning, atropine must be administered concomitantly to block the effects of the poison on these areas. Pralidoxime is also used to reverse the effects of overdosage of anticholinesterase agents used in the treatment of myasthenia gravis, i.e., neostigmine, pyridostigmine and ambenomium.

Categories

• 4 Antidotes and other substances used in poisonings
  • 4.2 Specific antidotes
  • 4.2.3 Organophosphate and carbamate poisoning

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Pralidoxime is contraindicated in conditions like Myasthenia gravis.

Drug Interactions

Side Effects

Dosage

Pralidoxime's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.01 to 0.07 mg/kg	0.04 (0.04)	0.5 hourly	IM	-
0.01 to 0.07 mg/kg	0.04 (0.04)	0.5 hourly	IV	-
1.43 to 4.28 mg/kg.min	2.9 (2.855)	As recommended.	IV Inf	For 15-30 Minutes
Paedriatic Dosage (20kg)
20 to 60 mg/kg	40 (40)	As recommended.	Slow IV	Single Dose, can be repeated As Required
Neonatal Dosage (3kg)
20 to 60 mg/kg	40 (40)	As recommended.	Slow IV	Single Dose, can be repeated As Required

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Pralidoxime

Manufacturers of Pralidoxime in Pakistan

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