Pralidoxime
Overview
Pralidoxime is a cholinesterase reactivator. Chemically Pralidoxime is 2-formyl-1-methylpyridinium. Pralidoxime is used as an antidote to reverse muscle paralysis resulting from organophosphate anticholinesterase pesticide poisoning. Because it does not significantly relieve depression of the respiratory center or decrease the muscarinic effects of anticholinesterase poisoning, atropine must be administered concomitantly to block the effects of the poison on these areas. Pralidoxime is also used to reverse the effects of overdosage of anticholinesterase agents used in the treatment of myasthenia gravis, i.e., neostigmine, pyridostigmine and ambenomium.
Categories
- 4 Antidotes and other substances used in poisonings
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Pralidoxime's dosage details are as follows:
Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
0.01 to 0.07 mg/kg | 0.04 (0.04) | 0.5 hourly | IM | - |
0.01 to 0.07 mg/kg | 0.04 (0.04) | 0.5 hourly | IV | - |
1.43 to 4.28 mg/kg.min | 2.9 (2.855) | As recommended. | IV Inf | For 15-30 Minutes |
Paedriatic Dosage (20kg)
|
20 to 60 mg/kg | 40 (40) | As recommended. | Slow IV | Single Dose, can be repeated As Required |
Neonatal Dosage (3kg)
|
20 to 60 mg/kg | 40 (40) | As recommended. | Slow IV | Single Dose, can be repeated As Required |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Pralidoxime
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