Pralidoxime

Overview

Pralidoxime is a cholinesterase reactivator. Chemically Pralidoxime is 2-formyl-1-methylpyridinium. Pralidoxime is used as an antidote to reverse muscle paralysis resulting from organophosphate anticholinesterase pesticide poisoning. Because it does not significantly relieve depression of the respiratory center or decrease the muscarinic effects of anticholinesterase poisoning, atropine must be administered concomitantly to block the effects of the poison on these areas. Pralidoxime is also used to reverse the effects of overdosage of anticholinesterase agents used in the treatment of myasthenia gravis, i.e., neostigmine, pyridostigmine and ambenomium.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

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Side Effects

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Dosage

Pralidoxime's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

0.01 to 0.07 mg/kg0.04 (0.04)0.5 hourlyIM-
0.01 to 0.07 mg/kg0.04 (0.04)0.5 hourlyIV-
1.43 to 4.28 mg/kg.min2.9 (2.855)As recommended.IV InfFor 15-30 Minutes

Paedriatic Dosage (20kg)

20 to 60 mg/kg40 (40)As recommended.Slow IVSingle Dose, can be repeated As Required

Neonatal Dosage (3kg)

20 to 60 mg/kg40 (40)As recommended.Slow IVSingle Dose, can be repeated As Required

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Pralidoxime

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Manufacturers of Pralidoxime in Pakistan

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