Prednisolone and Prednisone
Overview
Prednisone is the most commonly-prescribed oral corticosteroid. Chemically Prednisolone and Prednisone is 11ß, 17, 21-trihydroxypregna-1, 4-diene-3, 20-dione. The drug is metabolized in the liver to its active form, prednisolone. Relative to hydrocortisone, prednisone is roughly 4 times as potent as a glucocorticoid. Prednisolone and Prednisone is intermediate between hydrocortisone and dexamethasone in duration of action. Prednisone is used in many conditions, including allograft rejection, asthma, systemic lupus erythematosus, and many other inflammatory states. It has very little mineralocorticoid activity, so Prednisolone and Prednisone is not used in the management of adrenal insufficiency unless a more potent mineralocorticoid is administered concomitantly.
Categories
- 8 Antineoplastics, immunomodulators and drugs used in palliative care
- 18 Hormones and other endocrine drugs and contraceptives
Primary Characterstics
Indications
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Pharmacokinetics
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Side Effects
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Dosage
's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 5 to 60 mg | 32 (32.5) | As recommended. | PO,IM | In divided doses. |
| 0.5 to 1 % | 0.75 (0.75) | 8 hourly | Topical | |
Paedriatic Dosage (20kg)
|
| 125 to 300 ug/kg | 210 (212.5) | 8 hourly | Intra Muscular | |
| 125 to 300 ug/kg | 210 (212.5) | 8 hourly | Oral | |
| 0.5 % | 0.5 (0.5) | 8 hourly | Topical | |
Neonatal Dosage (3kg)
|
| | | | Shoul be avoided under 1 year |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
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Manufacturers of
Prednisolone and Prednisone
in Pakistan
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