Streptomycin

Overview

Streptomycin is an aminoglycoside antibiotic. It has a hexose ring, streptidine to which various amino sugars are attached by glycosidic linkages. Streptomycin is the first of the aminoglycoside antibiotic and was isolated from a strain of Streptomyces griseus by Waksman and his associates in 1944. Aminoglycoside frequently exibit synergism with a beta lactam antibiotc or vancomycin. In combination they eradicate organism more rapidly than a single agent. Aminoglycosides are polycations and their polarity accounts for their pharmakokinetic peopertie. Streptomycin is effective against a large variety of aerobic gram negative bacilli an some gram positive bacteria including mycobacteria. The use of Streptomycin is now limited because of the emergence of resistance. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Streptomycin is important to take the drug for the full time period as prescribed, discontinuation of the drug, may result in ineffective treatment.

Categories

• 6 Anti-infective drugs
  • 6.2 Antibiotics, systemic
    • 6.2.2 Other anti-bacterial drugs
      • 6.2.2.5 Aminoglycosides

• 6 Anti-infective drugs
  • 6.2 Antibiotics, systemic
  • 6.2.4 Anti-tuberculosis drugs

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

The severe or irreversible adverse effects of Streptomycin, which give rise to further complications include Deafness.

Streptomycin produces potentially life-threatening effects which include Agranulocytosis, Aplastic Anemia. which are responsible for the discontinuation of Streptomycin therapy.

The signs and symptoms that are produced after the acute overdosage of Streptomycin include Hemolytic anemia, Renal failure.

The symptomatic adverse reactions produced by Streptomycin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vertigo, Ataxia, Tinnitus, Urinary retensionX, Pain, Giddiness, Nystagmus, Pleocytosis, Neck pain.

Dosage

Magnesium Salicylate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
15 mg/ kg	15 (15)	24 hourly	IM	Maximum dose 1g/day
150 mg	150 (150)	24 hourly	PO
Paedriatic Dosage (20kg)
15 mg/kg	15 (15)	12 hourly	Intra Muscular	-
Neonatal Dosage (3kg)
15 mg/kg	15 (15)	12 hourly	Intra Muscular	-

High Risk Groups

Warning / Precautions

Storage Conditions

Inj

Store Below 40°C.

Interference in Pathology

Brands / Trade Names of Magnesium Salicylate

Manufacturers of Streptomycin in Pakistan

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