Gentamicin
Overview
Categories
- 6 Anti-infective drugs
- 6.2 Antibiotics, systemic
- 6.2.2 Other anti-bacterial drugs
- 13 Dermatological drugs (topical)
- 13.2 Anti-infectives, topical
- 21 Ophthalmological preparations
Primary Characterstics
Indications
Gentamicin is primarily indicated in conditions like Acute diarrhoea, Bacterial infections, Biliary tract infections, Endocarditis, Food allergy, Muscle relaxation (intermediate duration) during intensive care, Muscle relaxation (intermediate duration) for surgery or intubation, Muscle relaxation (long duration) during intensive care, Pneumonia in hospital patients, Septicaemia, Ulcerative colitis and crohn's disease, Urinary tract infection, and can also be given in adjunctive therapy as an alternative drug of choice in Solid tumor.
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Gentamicin's dosage details are as follows:
Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
120 mg | 120 (120) | As recommended. | | For prophylaxis in high risk patients before induction of anaesthesia |
160 mg | 160 (160) | As recommended. | | For urinary tract infections, if renal function is not impaired. |
4 to 8 mg | 6 (6) | As recommended. | Intra Thecal | As Required |
3 to 5 mg/kg | 4 (4) | As recommended. | IV,IM | In 3-4 divided doses for 7-10 days. Doses vary according to indication. |
0.3 % | 0.3 (0.3) | As recommended. | Optical | |
1 mg/kg/d | 1 (1) | 6 hourly | Otic | 1-2 drops |
1 mg/kg/dose | 1 (1) | 8 hourly | PO | For prevention of becterial endocarditis. NOT to exceed 80 mg with ampicillin (1-2g). 30 minutes prior to procedures. |
0.1 % | 0.1 (0.1) | 8 hourly | Topical | Or twice a day if needed. |
Paedriatic Dosage (20kg)
|
0.3 % | 0.3 (0.3) | 6 hourly | Ear | - |
2 to 1.5 mg/kg | 1.8 (1.75) | 8 hourly | Intra Muscular | |
2.5 mg/kg | 2.5 (2.5) | 8 hourly | Intra Venous | - |
0.3 % | 0.3 (0.3) | 6 hourly | Opthalmic | - |
0.3 % | 0.3 (0.3) | 6 hourly | Topical | - |
Neonatal Dosage (3kg)
|
2.5 mg/kg | 2.5 (2.5) | 8 hourly | Intramuscular | |
2.5 mg/kg | 2.5 (2.5) | 8 hourly | Intravenous | |
0.3 % | 0.3 (0.3) | 6 hourly | Topical | |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Gentamicin
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