Mannitol

Overview

Mannitol most extensively employed as osmotic diuretic. its D-enantiomer is used clinically.it opposes reabsorption of water which normally accompanies sodium reabsorption from kidney tubule. Used when there is a danger renal failure (e.g shock, cardiovascular surgery) and in fluid overload refactory to other diuretics. May cause cardiac failure owing to increase circulating blood volume. Mannitoladministered by intravenous infusion.

Categories

• 16 Diuretics
  • 16.4 Osmotic diuretics

• 26 Hospital fluids
  • 26.2 Parentral solutions
  • 26.2.5 Osmotic therapy solutions

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Mannitol's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
50 to 100 g	75 (75)	24 hourly	IV Inf	Initial dose
15 to 25 %	20 (20)	24 hourly	IV Inf
0.2 g/ kg/dose	0.2 (0.2)	As recommended.	IV Inf	Test Dose, Max. 12.5gm over 3-5 min, If there is no diuresis within 2 hrs. discontinue mannitol
0.25 to 0.5 g/ kg	0.38 (0.375)	6 hourly	IV Inf	Maintenance dose
Paedriatic Dosage (20kg)
0.25 to 0 g/ug	0.12 (0.125)	As recommended.
16.66 to 66.66 mg/kg.min	42 (41.66)	As recommended.	IV Infusion	Once for 30 Minutes .Can be repeated
Neonatal Dosage (3kg)
16.66 to 66.66 mg/kg.min	42 (41.66)	As recommended.	IV Infusion	Infuse over 30 min.Repeat the dose as required

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Mannitol

Manufacturers of Mannitol in Pakistan

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